Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:476
Official Symbol:ATP1A1
Other Aliases:MGC3285|MGC51750
See related:HGNC:799|MIM:182310|HPRD:01662
Chromosome:1
Location:1p21
Gene Description:ATPase, Na+/K+ transporting, alpha 1 polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0551
ORGANISM:human
Entrez Gene ID:476
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24211
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11928CBCerebellum100.0100.0
11928CTXCerebral cortex100.0100.0
11928HIPHippocampal region100.0100.0
11928HPFHippocampal formation100.0100.0
11928HYHypothalamus84.734893798828189.1150894165039
11928LSXLateral septal complex100.0100.0
11928MBMidbrain77.969198226928784.6244239807129
11928MYMedulla78.757244110107494.6927108764648
11928OLFOlfactory bulb100.0100.0
11928PPons69.911888122558679.1876411437988
11928PALPallidum80.479198455810587.9320831298828
11928RHPRetrohippocampal region100.0100.0
11928sAMYStriatum-like amygdalar nuclei100.0100.0
11928STRStriatum100.0100.0
11928STRdStriatum dorsal region100.0100.0
11928STRvStriatum ventral region100.0100.0
11928THThalamus93.2643127441406100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
476GO:0000166IEAFunctionnucleotide binding
476GO:0000287IEAFunctionmagnesium ion binding
476GO:0005391ISSFunctionsodium:potassium-exchanging ATPase activity
476GO:0005515IPIFunctionprotein binding
476GO:0005524IEAFunctionATP binding
476GO:0005624TASComponentmembrane fraction
476GO:0005890ISSComponentsodium:potassium-exchanging ATPase complex
476GO:0006812IEAProcesscation transport
476GO:0006813ISSProcesspotassium ion transport
476GO:0006814ISSProcesssodium ion transport
476GO:0008152IEAProcessmetabolism
476GO:0015077IEAFunctionmonovalent inorganic cation transporter activity
476GO:0015662IEAFunctionATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
476GO:0015991ISSProcessATP hydrolysis coupled proton transport
476GO:0016020IEAComponentmembrane
476GO:0016787IEAFunctionhydrolase activity
476GO:0016820IEAFunctionhydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
476GO:0030317ISSProcesssperm motility
476GO:0030641ISSProcesshydrogen ion homeostasis
476GO:0030955IEAFunctionpotassium ion binding
476GO:0031402IEAFunctionsodium ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5595NP_002737.1mitogen-activated protein kinase 3HPRD03479
-5348NP_005022.2phospholemman precursorHPRD03837
-1072NP_005498.1cofilin 1 (non-muscle)HPRD03261
-53822NP_071289.1FXYD domain-containing ion transport regulator 7HPRD09457
NP_000692.21072-Cofilin 1HPRD01662
NP_000692.253822-FXYD domain containing ion transport regulator 7HPRD01662
NP_000692.25348-PhospholemmanHPRD01662
NP_000692.25595-ERK1HPRD01662
NP_000692.27132NP_001056.1tumor necrosis factor receptor 1 precursorHPRD01662
NP_000692.27133NP_001057.1tumor necrosis factor receptor 2 precursorHPRD01662
NP_000692.27178NP_003286.1tumor protein, translationally-controlled 1HPRD01662
NP_000692.27178NP_003286.1tumor protein, translationally-controlled 1HPRD15979
NP_000692.28717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD04610
NP_000692.28717NP_003780.1TNFRSF1A-associated via death domain isoform 1HPRD01662
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
476IPR006069ATPase_cat_aATPase, P-type cation exchange, alpha subunit
476IPR001757ATPase_PATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
476IPR004014ATPase_P_cat_NATPase, P-type cation-transporter, N-terminal
476IPR005834Dehal_like_hydroHaloacid dehalogenase-like hydrolase
476IPR008250E1-E2_ATPase_regE1-E2 ATPase-associated region
476AT1A1_HUMANP05023IPR006069ATPase_cat_aATPase, P-type cation exchange, alpha subunit
476AT1A1_HUMANP05023IPR001757ATPase_PATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
476AT1A1_HUMANP05023IPR004014ATPase_P_cat_NATPase, P-type cation-transporter, N-terminal
476AT1A1_HUMANP05023IPR006068ATPase_P_cat_CATPase, P-type cation-transporter, C-terminal
476AT1A1_HUMANP05023IPR005834Dehal_like_hydroHaloacid dehalogenase-like hydrolase
476AT1A1_HUMANP05023IPR008250E1-E2_ATPase_regE1-E2 ATPase-associated region
476AT1A1_HUMANP05023IPR000695H_ATPaseH+ transporting ATPase, proton pump

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