Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4781
Official Symbol:NFIB
Other Aliases:NFI-RED|NFIB2|NFIB3
See related:HGNC:7785|MIM:600728|HPRD:09008
Chromosome:9
Location:9p24.1
Gene Description:nuclear factor I/B
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0035
ORGANISM:human
Entrez Gene ID:4781
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18028
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0220
ORGANISM:human
Entrez Gene ID:4781
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
KARG Evidence 3
KARG ID:HOT0296
ORGANISM:human
Entrez Gene ID:4781
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18028CBCerebellum38.577852249145558.7606887817383
18028CTXCerebral cortex58.500652313232444.8523578643799
18028HIPHippocampal region72.011863708496191.1952514648438
18028HPFHippocampal formation67.682037353515676.7417755126953
18028HYHypothalamus4.150315642356872.65172910690308
18028LSXLateral septal complex23.636462211608916.4201231002808
18028MBMidbrain9.23692703247078.53300881385803
18028MYMedulla24.946314811706525.5062446594238
18028OLFOlfactory bulb68.321144104003955.8281860351562
18028PPons27.325832366943427.313777923584
18028PALPallidum7.979192018508916.28113532066345
18028RHPRetrohippocampal region59.661432266235451.3431835174561
18028sAMYStriatum-like amygdalar nuclei12.924449920654310.3187782764435
18028STRStriatum12.208467006683310.0531916618347
18028STRdStriatum dorsal region9.883266448974619.10653138160706
18028STRvStriatum ventral region11.86615943908697.11374807357788
18028THThalamus4.752233028411874.12824773788452
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4781GO:0003700IEAFunctiontranscription factor activity
4781GO:0003700TASFunctiontranscription factor activity
4781GO:0005634IEAComponentnucleus
4781GO:0005634TASComponentnucleus
4781GO:0006260IEAProcessDNA replication
4781GO:0006350IEAProcesstranscription
4781GO:0006355IEAProcessregulation of transcription, DNA-dependent
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4784NP_002492.1nuclear factor I/X (CCAAT-binding transcription factor)HPRD01234
NP_005587.1--NFICHPRD09008
NP_005587.14784-Nuclear factor I/XHPRD09008
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4781NFIB_HUMANO00712IPR000647CTF_NFICTF/NF-I
4781NFIB_HUMANO00712IPR003619Dwarfin_ADwarfin protein, A
4781NFIB_HUMANO00712IPR000694PRO_richProline-rich region

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