Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4790
Official Symbol:NFKB1
Other Aliases:DKFZp686C01211|EBP-1|KBF1|MGC54151|NF-kappa-B|NFKB-p105|NFKB-p50
See related:HGNC:7794|MIM:164011|HPRD:01238
Chromosome:4
Location:4q24
Gene Description:nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0568
ORGANISM:human
Entrez Gene ID:4790
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:81736
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4790GO:0003700TASFunctiontranscription factor activity
4790GO:0005515IPIFunctionprotein binding
4790GO:0005634IDAComponentnucleus
4790GO:0005737IDAComponentcytoplasm
4790GO:0006355IEAProcessregulation of transcription, DNA-dependent
4790GO:0006366TASProcesstranscription from RNA polymerase II promoter
4790GO:0006915IEAProcessapoptosis
4790GO:0006916TASProcessanti-apoptosis
4790GO:0006954TASProcessinflammatory response
4790GO:0007165IEAProcesssignal transduction
4790GO:0009618TASProcessresponse to pathogenic bacteria
4790GO:0019733TASProcessantibacterial humoral response (sensu Vertebrata)
4790GO:0045941NASProcesspositive regulation of transcription
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6688NP_003111.1spleen focus forming virus (SFFV) proviral integration oncogene spi1HPRD01305
-6778NP_003144.3signal transducer and activator of transcription 6HPRD03302
-7295NP_003320.1thioredoxinHPRD01761
-8648NP_003734.3nuclear receptor coactivator 1 isoform 1HPRD04070
-4794NP_004547.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilonHPRD05181
-9612NP_006303.1nuclear receptor co-repressor 2HPRD02910
-9908NP_036429.2Ras-GTPase activating protein SH3 domain-binding protein 2 isoform aHPRD06570
-9325NP_057297.2thyroid hormone receptor interactor 4HPRD05140
-51773NP_057662.3remodeling and spacing factor 1HPRD10537
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
-136319NP_665807.1myotrophinHPRD07574
NP_003989.1--Interleukin 1 induced nuclear ankyrin repeat proteinHPRD01238
NP_003989.1--Gas6HPRD01238
NP_003989.1--cdk9HPRD01238
NP_003989.17295-ThioredoxinHPRD01238
NP_003989.15970-NFKB3HPRD01238
NP_003989.16688-SPI1HPRD01238
NP_003989.14794-NF kappa B inhibitor epsilonHPRD01238
NP_003989.18648-SRC1HPRD01238
NP_003989.16778-STAT6HPRD01238
NP_003989.14792-I kappa B alphaHPRD01238
NP_003989.19612-Nuclear receptor corepressor 2HPRD01238
NP_003989.19908-Ras-GTPase activating protein binding protein 2HPRD01238
NP_003989.1136319-MyotrophinHPRD01238
NP_003989.16774-STAT3HPRD01238
NP_003989.19325-Thyroid hormone receptor interactor 4HPRD01238
NP_003989.17175AAB48030.1Human nuclear pore complex-associated protein TPR (tpr) mRNA, and translated productsHPRD08927
NP_003989.15531NP_002711.1protein phosphatase 4 (formerly X), catalytic subunitHPRD03615
NP_003989.15531NP_002711.1protein phosphatase 4 (formerly X), catalytic subunitHPRD01238
NP_003989.16256NP_002948.1retinoid X receptor, alphaHPRD01577
NP_003989.16256NP_002948.1retinoid X receptor, alphaHPRD01238
NP_003989.18091NP_003474.1high mobility group AT-hook 2 isoform aHPRD02827
NP_003989.18091NP_003474.1high mobility group AT-hook 2 isoform aHPRD01238
NP_003989.18600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD04031
NP_003989.18600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD01238
NP_003989.19043NP_003962.3sperm associated antigen 9 isoform 1HPRD10398
NP_003989.17278NP_005992.1tubulin, alpha 2 isoform 1HPRD03958
NP_003989.110627NP_006462.1myosin regulatory light chain MRCL3HPRD14735
NP_003989.110856NP_006657.1RuvB-like 2HPRD16070
NP_003989.123421NP_055103.3integrin beta 3 binding protein (beta3-endonexin)HPRD01238
NP_003989.123421NP_055103.3integrin beta 3 binding protein (beta3-endonexin)HPRD09267
NP_003989.14851NP_060087.2notch1 preproproteinHPRD01827
NP_003989.14851NP_060087.2notch1 preproproteinHPRD01238
NP_003989.14792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaHPRD01235
NP_003989.179155NP_077285.2A20-binding inhibitor of NF-kappaB activation 2HPRD18207
NP_003989.184617NP_115914.1tubulin, beta 6HPRD11349
NP_003989.1222643NP_775832.1unc-5 homolog C-likeHPRD01238
NP_003989.1347733NP_821080.1tubulin, beta polypeptide paralogHPRD14707
NP_003989.2---BIND183788
NP_003989.29043--BIND209939
NP_003989.210524--BIND262100
NP_003989.28648NP_003734.3nuclear receptor coactivator 1 isoform 1BIND151107
NP_003989.24790NP_003989.2nuclear factor kappa-B, subunit 1BIND151756
NP_003989.24790NP_003989.2nuclear factor kappa-B, subunit 1BIND259610
NP_003989.210856NP_006657.1RuvB-like 2BIND259801
NP_003989.24792NP_065390.1nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaBIND182788
NP_003989.25970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND154046
NP_003989.25970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND259611
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155807NP_057852.2Vpr--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155871NP_057853.1Tat--
NP_003989.2155945NP_057855.1Vpu--
NP_003989.2155030NP_579881.1nucleocapsid--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4790NFKB1_HUMANP19838IPR002110ANKAnkyrin
4790NFKB1_HUMANP19838IPR000488DeathDeath
4790NFKB1_HUMANP19838IPR003907Galnin_2_rcptGalanin 2 receptor
4790NFKB1_HUMANP19838IPR002909IPT_TIG_rcptCell surface receptor IPT/TIG
4790NFKB1_HUMANP19838IPR000451NF_Rel_dorNF-kappa-B/Rel/dorsal
4790NFKB1_HUMANP19838IPR011539RHDRel homology
4790NFKB1_HUMANP19838IPR013555TRP_2Transient receptor ion channel II

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