Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4792
Official Symbol:NFKBIA
Other Aliases:IKBA|MAD-3|NFKBI
See related:HGNC:7797|MIM:164008|HPRD:01235
Chromosome:14
Location:14q13
Gene Description:nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0141
ORGANISM:human
Entrez Gene ID:4792
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18035
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0562
ORGANISM:human
Entrez Gene ID:4792
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25493
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18035CBCerebellum24.975208282470736.463695526123
18035CTXCerebral cortex11.851368904113810.0741147994995
18035HIPHippocampal region15.603064537048318.6789283752441
18035HPFHippocampal formation13.512173652648914.853232383728
18035HYHypothalamus5.423191070556645.2316198348999
18035LSXLateral septal complex11.55007934570318.93486881256104
18035MBMidbrain9.0861358642578111.8897266387939
18035MYMedulla15.034126281738318.0437030792236
18035OLFOlfactory bulb13.146672248840311.0877847671509
18035PPons8.6681194305419911.3491373062134
18035PALPallidum8.721660614013679.53819274902344
18035RHPRetrohippocampal region10.877136230468810.13512134552
18035sAMYStriatum-like amygdalar nuclei28.599170684814526.2584476470947
18035STRStriatum12.989697456359911.9057741165161
18035STRdStriatum dorsal region12.322795867919911.5257415771484
18035STRvStriatum ventral region6.883772373199465.47969579696655
18035THThalamus15.739381790161117.7815856933594
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4792GO:0005634IDAComponentnucleus
4792GO:0005737IDAComponentcytoplasm
4792GO:0006915TASProcessapoptosis
4792GO:0007253NASProcesscytoplasmic sequestering of NF-kappaB
4792GO:0008139IPIFunctionnuclear localization sequence binding
4792GO:0009618TASProcessresponse to pathogenic bacteria
4792GO:0031625IPIFunctionubiquitin protein ligase binding
4792GO:0042345NASProcessregulation of NF-kappaB import into nucleus
4792GO:0043392NASProcessnegative regulation of DNA binding
4792GO:0051059IPIFunctionNF-kappaB binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7157NP_000537.2tumor protein p53HPRD01859
-6195NP_002944.2ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform aHPRD03402
-8600NP_003692.1tumor necrosis factor ligand superfamily, member 11 isoform 1HPRD04031
-7278NP_005992.1tubulin, alpha 2 isoform 1HPRD03958
-10376NP_006073.1tubulin, alpha, ubiquitousHPRD03960
-9908NP_036429.2Ras-GTPase activating protein SH3 domain-binding protein 2 isoform aHPRD06570
-23291NP_036432.1F-box and WD-40 domain protein 1B isoform CHPRD07294
-8945NP_378663.1beta-transducin repeat containing protein isoform 1HPRD04596
NP_065390.1---BIND185168
NP_065390.1---BIND185169
NP_065390.1---BIND185167
NP_065390.1---BIND262380
NP_065390.1---BIND196525
NP_065390.1---BIND312474
NP_065390.16195-Ribosomal S6 kinase 1HPRD01235
NP_065390.110376-Tubulin, alpha, ubiquitousHPRD01235
NP_065390.17278-Tubulin, alpha 2HPRD01235
NP_065390.18945-Beta transducin repeat containing proteinHPRD01235
NP_065390.18600-Tumor necrosis factor ligand superfamily, member 11HPRD01235
NP_065390.123291-Beta TrCP2HPRD01235
NP_065390.19908-Ras-GTPase activating protein binding protein 2HPRD01235
NP_065390.17157-p53HPRD01235
NP_065390.192609NP_001001563.1translocase of inner mitochondrial membrane 50 homologHPRD12118
NP_065390.1387082NP_001002255.1SMT3 suppressor of mif two 3 homolog 4HPRD10584
NP_065390.18655NP_003737.1dynein light chain 1HPRD03334
NP_065390.18655NP_003737.1dynein light chain 1HPRD01235
NP_065390.18655NP_003737.1dynein light chain 1BIND295889
NP_065390.18841NP_003874.2histone deacetylase 3BIND182506
NP_065390.18945NP_003930.1beta-transducin repeat containing protein isoform 2BIND181874
NP_065390.110477NP_006348.1ubiquitin-conjugating enzyme E2E 3HPRD05000
NP_065390.110477NP_006348.1ubiquitin-conjugating enzyme E2E 3HPRD01235
NP_065390.17415NP_009057.1valosin-containing proteinHPRD01235
NP_065390.17415NP_009057.1valosin-containing proteinHPRD03013
NP_065390.123085NP_055879.1RAB6-interacting protein 2 isoform alphaBIND146171
NP_065390.151065NP_057004.1ribosomal protein S27-likeHPRD18003
NP_065390.155140NP_060561.3elongation protein 3 homologHPRD10936
NP_065390.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND54981
NP_065390.15970NP_068810.2v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65BIND133987
NP_065390.15783NP_542416.1protein tyrosine phosphatase, non-receptor type 13 isoform 4HPRD02602
NP_065390.15783NP_542416.1protein tyrosine phosphatase, non-receptor type 13 isoform 4HPRD01235
NP_065390.1150684NP_689729.1MURR1BIND54928
NP_065390.15295NP_852664.1phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1HPRD01235
NP_065390.1155807NP_057852.2Vpr--
NP_065390.1155871NP_057853.1Tat--
NP_065390.1155871NP_057853.1Tat--
NP_065390.1155908NP_057854.1Rev--
NP_065390.1155945NP_057855.1Vpu--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4792IKBA_HUMANP25963IPR002110ANKAnkyrin
4792IKBA_HUMANP25963IPR013555TRP_2Transient receptor ion channel II

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