Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:48
Official Symbol:ACO1
Other Aliases:IREB1|IREBP|IRP1
See related:HGNC:117|MIM:100880|HPRD:00013
Chromosome:9
Location:9p22-q32|9p22-p13
Gene Description:aconitase 1, soluble
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0264
ORGANISM:human
Entrez Gene ID:48
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Downregulated
Fold Change:-0.58
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11428CBCerebellum16.398300647735617.0849809646606
11428CTXCerebral cortex32.424406051635712.9692115783691
11428HIPHippocampal region12.49255394935619.05292558670044
11428HPFHippocampal formation15.71672868728649.45733094215393
11428HYHypothalamus8.610608577728273.29482889175415
11428LSXLateral septal complex5.889268636703492.08697509765625
11428MBMidbrain12.72095441818246.62404119968414
11428MYMedulla21.870079517364513.6317266225815
11428OLFOlfactory bulb35.190004348754918.5372858047485
11428PPons17.39776897430429.81872451305389
11428PALPallidum12.23802709579474.86350393295288
11428RHPRetrohippocampal region21.368087768554710.2583547830582
11428sAMYStriatum-like amygdalar nuclei5.093146324157711.86301881074905
11428STRStriatum5.527362108230592.15904265642166
11428STRdStriatum dorsal region3.981494426727291.52725785970688
11428STRvStriatum ventral region9.964565753936773.85527920722961
11428THThalamus9.975988149642943.89368534088135
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
48GO:0003723IDAFunctionRNA binding
48GO:0003723NASFunctionRNA binding
48GO:0003994IDAFunctionaconitate hydratase activity
48GO:0005506IEAFunctioniron ion binding
48GO:0005737NASComponentcytoplasm
48GO:0006099IEAProcesstricarboxylic acid cycle
48GO:0008152IEAProcessmetabolism
48GO:0016829IEAFunctionlyase activity
48GO:0046872IEAFunctionmetal ion binding
48GO:0051539IEAFunction4 iron, 4 sulfur cluster binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
48IREB1_HUMANP21399IPR000573Aconitase_CAconitate hydratase, C-terminal
48IREB1_HUMANP21399IPR001030Aconitase_NAconitate hydratase, N-terminal

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