Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4852
Official Symbol:NPY
Other Aliases:PYY4
See related:HGNC:7955|MIM:162640|HPRD:01214
Chromosome:7
Location:7p15.1
Gene Description:neuropeptide Y
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0396
ORGANISM:human
Entrez Gene ID:4852
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:24604
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0399
ORGANISM:human
Entrez Gene ID:4852
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:1.2 :: -1.2 :: -1.9 :: -2.2 :: -1.5 :: -1.8
KARG Evidence 3
KARG ID:EVIM0467
ORGANISM:human
Entrez Gene ID:4852
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.5 :: -1.5 :: -1.7 :: 1.6 :: -1.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
109648CBCerebellum3.032031714916234.01374661922455
109648CTXCerebral cortex19.950479507446338.169303894043
109648HIPHippocampal region12.488897800445631.9447793960571
109648HPFHippocampal formation12.765607833862328.530930519104
109648HYHypothalamus5.676242828369149.70335006713867
109648LSXLateral septal complex4.8390048742294310.9404208660126
109648MBMidbrain4.396640777587897.49322581291199
109648MYMedulla4.17067146301276.40743398666382
109648OLFOlfactory bulb19.799283981323232.8686542510986
109648PPons1.384982794523241.70349550247192
109648PALPallidum5.5180859565734911.0702223777771
109648RHPRetrohippocampal region12.874607086181623.2285995483398
109648sAMYStriatum-like amygdalar nuclei12.471445560455322.1652140617371
109648STRStriatum9.2204251289367721.5682401657104
109648STRdStriatum dorsal region8.3577513694763221.7302722930908
109648STRvStriatum ventral region11.778684616088924.1847667694092
109648THThalamus3.918856382376.27925109863281
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4852GO:0004930TASFunctionG-protein coupled receptor activity
4852GO:0005184TASFunctionneuropeptide hormone activity
4852GO:0005246TASFunctioncalcium channel regulator activity
4852GO:0005576IEAComponentextracellular region
4852GO:0005623TASComponentcell
4852GO:0006816TASProcesscalcium ion transport
4852GO:0006928TASProcesscell motility
4852GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
4852GO:0007218IEAProcessneuropeptide signaling pathway
4852GO:0007268TASProcesssynaptic transmission
4852GO:0007586NASProcessdigestion
4852GO:0007631TASProcessfeeding behavior
4852GO:0008015NASProcesscirculation
4852GO:0008283TASProcesscell proliferation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-4886NP_000900.1neuropeptide Y receptor Y1HPRD01215
-4887NP_000901.1neuropeptide Y receptor Y2HPRD01216
-8620NP_003708.1neuropeptide FF-amide peptide precursorHPRD06869
-5540NP_005963.2pancreatic polypeptide receptor 1HPRD03476
-4889NP_006165.1neuropeptide Y receptor Y5HPRD03591
-51738NP_057446.1ghrelin precursorHPRD05638
NP_000896.1--Neuropeptide Y y6 receptorHPRD01214
NP_000896.14886-Neuropeptide Y receptor type 1HPRD01214
NP_000896.14887-Neuropeptide Y receptor type 2HPRD01214
NP_000896.151738-GhrelinHPRD01214
NP_000896.18620-Neuropeptide FF amide peptideHPRD01214
NP_000896.14889-Neuropeptide Y receptor type 5HPRD01214
NP_000896.15540-Pancreatic polypeptide receptor 1HPRD01214
NP_000896.15367-Pro melanin concentrating hormoneHPRD01214
NP_000896.110886NP_004876.1G protein-coupled receptor 74 isoform 1HPRD16244
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4852NEUY_HUMANP01303IPR001955Pancreatic_hormnPancreatic hormone

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