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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 4852 Official Symbol: NPY Other Aliases: PYY4 See related: HGNC:7955|MIM:162640|HPRD:01214 Chromosome: 7 Location: 7p15.1 Gene Description: neuropeptide Y Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0396 ORGANISM: human Entrez Gene ID: 4852 Evidence Type: Mapping from rat Evidence ID Type: Entrez Gene Evidence ID: 24604 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: KARG Evidence 2 KARG ID: EVIM0399 ORGANISM: human Entrez Gene ID: 4852 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12065639 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Frontal Cortex Drug Effects: Downregulated Fold Change: 1.2 :: -1.2 :: -1.9 :: -2.2 :: -1.5 :: -1.8 KARG Evidence 3 KARG ID: EVIM0467 ORGANISM: human Entrez Gene ID: 4852 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 12065639 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Motor Cortex Drug Effects: Downregulated Fold Change: -1.5 :: -1.5 :: -1.7 :: 1.6 :: -1.1 Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 109648 CB Cerebellum 3.03203171491623 4.01374661922455 109648 CTX Cerebral cortex 19.9504795074463 38.169303894043 109648 HIP Hippocampal region 12.4888978004456 31.9447793960571 109648 HPF Hippocampal formation 12.7656078338623 28.530930519104 109648 HY Hypothalamus 5.67624282836914 9.70335006713867 109648 LSX Lateral septal complex 4.83900487422943 10.9404208660126 109648 MB Midbrain 4.39664077758789 7.49322581291199 109648 MY Medulla 4.1706714630127 6.40743398666382 109648 OLF Olfactory bulb 19.7992839813232 32.8686542510986 109648 P Pons 1.38498279452324 1.70349550247192 109648 PAL Pallidum 5.51808595657349 11.0702223777771 109648 RHP Retrohippocampal region 12.8746070861816 23.2285995483398 109648 sAMY Striatum-like amygdalar nuclei 12.4714455604553 22.1652140617371 109648 STR Striatum 9.22042512893677 21.5682401657104 109648 STRd Striatum dorsal region 8.35775136947632 21.7302722930908 109648 STRv Striatum ventral region 11.7786846160889 24.1847667694092 109648 TH Thalamus 3.91885638237 6.27925109863281 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 4852 GO:0004930 TAS Function G-protein coupled receptor activity 4852 GO:0005184 TAS Function neuropeptide hormone activity 4852 GO:0005246 TAS Function calcium channel regulator activity 4852 GO:0005576 IEA Component extracellular region 4852 GO:0005623 TAS Component cell 4852 GO:0006816 TAS Process calcium ion transport 4852 GO:0006928 TAS Process cell motility 4852 GO:0007187 TAS Process G-protein signaling, coupled to cyclic nucleotide second messenger 4852 GO:0007218 IEA Process neuropeptide signaling pathway 4852 GO:0007268 TAS Process synaptic transmission 4852 GO:0007586 NAS Process digestion 4852 GO:0007631 TAS Process feeding behavior 4852 GO:0008015 NAS Process circulation 4852 GO:0008283 TAS Process cell proliferation Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID - 4886 NP_000900.1 neuropeptide Y receptor Y1 HPRD 01215 - 4887 NP_000901.1 neuropeptide Y receptor Y2 HPRD 01216 - 8620 NP_003708.1 neuropeptide FF-amide peptide precursor HPRD 06869 - 5540 NP_005963.2 pancreatic polypeptide receptor 1 HPRD 03476 - 4889 NP_006165.1 neuropeptide Y receptor Y5 HPRD 03591 - 51738 NP_057446.1 ghrelin precursor HPRD 05638 NP_000896.1 - - Neuropeptide Y y6 receptor HPRD 01214 NP_000896.1 4886 - Neuropeptide Y receptor type 1 HPRD 01214 NP_000896.1 4887 - Neuropeptide Y receptor type 2 HPRD 01214 NP_000896.1 51738 - Ghrelin HPRD 01214 NP_000896.1 8620 - Neuropeptide FF amide peptide HPRD 01214 NP_000896.1 4889 - Neuropeptide Y receptor type 5 HPRD 01214 NP_000896.1 5540 - Pancreatic polypeptide receptor 1 HPRD 01214 NP_000896.1 5367 - Pro melanin concentrating hormone HPRD 01214 NP_000896.1 10886 NP_004876.1 G protein-coupled receptor 74 isoform 1 HPRD 16244 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 4852 NEUY_HUMAN P01303 IPR001955 Pancreatic_hormn Pancreatic hormone © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.