Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4860
Official Symbol:NP
Other Aliases:MGC117396|MGC125915|MGC125916|PNP|PRO1837
See related:HGNC:7892|MIM:164050|HPRD:01247
Chromosome:14
Location:14q13.1
Gene Description:nucleoside phosphorylase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0221
ORGANISM:human
Entrez Gene ID:4860
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18950CBCerebellum0.4207475483417510.94881397485733
18950CTXCerebral cortex0.9145477414131161.05423617362976
18950HIPHippocampal region1.526838421821591.8343939781189
18950HPFHippocampal formation1.066589832305911.16102612018585
18950HYHypothalamus0.9984348416328431.05899667739868
18950LSXLateral septal complex1.072253942489620.5789395570755
18950MBMidbrain1.075956821441651.59147965908051
18950MYMedulla1.629316806793212.42656016349792
18950OLFOlfactory bulb2.166460990905762.8098464012146
18950PPons0.3700487613677980.596857845783234
18950PALPallidum0.4036134481430050.317323625087738
18950RHPRetrohippocampal region0.1642345190048220.120353430509567
18950sAMYStriatum-like amygdalar nuclei0.4989737272262570.526630997657776
18950STRStriatum0.9869758486747740.734067380428314
18950STRdStriatum dorsal region0.996667027473450.809181571006775
18950STRvStriatum ventral region1.093949675560.60998946428299
18950THThalamus4.784727096557626.13342380523682
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4860GO:0004731TASFunctionpurine-nucleoside phosphorylase activity
4860GO:0006139TASProcessnucleobase, nucleoside, nucleotide and nucleic acid metabolism
4860GO:0006304TASProcessDNA modification
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4860PNPH_HUMANP00491IPR001369Mtap_PNPPurine phosphorylase, family 2

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