Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4862
Official Symbol:NPAS2
Other Aliases:FLJ23138|MGC71151|MOP4|PASD4
See related:HGNC:7895|MIM:603347|HPRD:09137
Chromosome:2
Location:2q11.2
Gene Description:neuronal PAS domain protein 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0094
ORGANISM:human
Entrez Gene ID:4862
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18143
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18143CBCerebellum6.4146272242069210.7161831557751
18143CTXCerebral cortex52.769159317016641.1371088027954
18143HIPHippocampal region12.555191516876214.8005409240723
18143HPFHippocampal formation26.444825172424327.5313100814819
18143HYHypothalamus1.945281997323041.54082800447941
18143LSXLateral septal complex28.76190853118922.2551984786987
18143MBMidbrain2.973237395286563.2865446805954
18143MYMedulla2.183410763740543.12129110097885
18143OLFOlfactory bulb16.545381069183313.0148868560791
18143PPons1.90479567646982.19977688789368
18143PALPallidum7.353536367416386.27566933631897
18143RHPRetrohippocampal region50.099094390869145.541072845459
18143sAMYStriatum-like amygdalar nuclei13.312176227569610.5666129589081
18143STRStriatum62.592500686645548.2502346038818
18143STRdStriatum dorsal region73.859653472900456.951135635376
18143STRvStriatum ventral region72.122402191162154.3999786376953
18143THThalamus12.22840261459359.56902265548706
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4862GO:0003700IEAFunctiontranscription factor activity
4862GO:0003700TASFunctiontranscription factor activity
4862GO:0004871IEAFunctionsignal transducer activity
4862GO:0005634IEAComponentnucleus
4862GO:0006355IEAProcessregulation of transcription, DNA-dependent
4862GO:0007165IEAProcesssignal transduction
4862GO:0007417TASProcesscentral nervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002509.28202NP_006525.1nuclear receptor coactivator 3HPRD03570
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4862NPAS2_HUMANQ99743IPR001092HLH_basicBasic helix-loop-helix dimerisation region bHLH
4862NPAS2_HUMANQ99743IPR001067Nuc_translocatNuclear translocator
4862NPAS2_HUMANQ99743IPR000014PASPAS
4862NPAS2_HUMANQ99743IPR013655PAS_3PAS fold-3
4862NPAS2_HUMANQ99743IPR013767PAS_foldPAS fold

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