Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:490
Official Symbol:ATP2B1
Other Aliases:PMCA1
See related:HGNC:814|MIM:108731|HPRD:00158
Chromosome:12
Location:12q21.3
Gene Description:ATPase, Ca++ transporting, plasma membrane 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0547
ORGANISM:human
Entrez Gene ID:490
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29598
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
67972CBCerebellum100.0100.0
67972CTXCerebral cortex100.0100.0
67972HIPHippocampal region100.0100.0
67972HPFHippocampal formation100.0100.0
67972HYHypothalamus100.075.296989440918
67972LSXLateral septal complex100.0100.0
67972MBMidbrain100.070.2603454589844
67972MYMedulla100.087.6076889038086
67972OLFOlfactory bulb100.0100.0
67972PPons95.198875427246174.3962631225586
67972PALPallidum100.088.7201614379883
67972RHPRetrohippocampal region100.0100.0
67972sAMYStriatum-like amygdalar nuclei100.0100.0
67972STRStriatum100.0100.0
67972STRdStriatum dorsal region100.0100.0
67972STRvStriatum ventral region100.0100.0
67972THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
490GO:0000166IEAFunctionnucleotide binding
490GO:0000287IEAFunctionmagnesium ion binding
490GO:0005388TASFunctioncalcium-transporting ATPase activity
490GO:0005509IEAFunctioncalcium ion binding
490GO:0005516IEAFunctioncalmodulin binding
490GO:0005524IEAFunctionATP binding
490GO:0005887TASComponentintegral to plasma membrane
490GO:0006812IEAProcesscation transport
490GO:0006816IEAProcesscalcium ion transport
490GO:0008152IEAProcessmetabolism
490GO:0016020IEAComponentmembrane
490GO:0016787IEAFunctionhydrolase activity
490GO:0016820IEAFunctionhydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
490IPR001757ATPase_PATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
490IPR004014ATPase_P_cat_NATPase, P-type cation-transporter, N-terminal
490IPR006068ATPase_P_cat_CATPase, P-type cation-transporter, C-terminal
490IPR005834Dehal_like_hydroHaloacid dehalogenase-like hydrolase
490IPR008250E1-E2_ATPase_regE1-E2 ATPase-associated region
490AT2B1_HUMANP20020IPR001757ATPase_PATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
490AT2B1_HUMANP20020IPR004014ATPase_P_cat_NATPase, P-type cation-transporter, N-terminal
490AT2B1_HUMANP20020IPR006068ATPase_P_cat_CATPase, P-type cation-transporter, C-terminal
490AT2B1_HUMANP20020IPR005834Dehal_like_hydroHaloacid dehalogenase-like hydrolase
490AT2B1_HUMANP20020IPR008250E1-E2_ATPase_regE1-E2 ATPase-associated region

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