Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4900
Official Symbol:NRGN
Other Aliases:RC3|hng
See related:HGNC:8000|MIM:602350|HPRD:03828
Chromosome:11
Location:11q24
Gene Description:neurogranin (protein kinase C substrate, RC3)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0398
ORGANISM:human
Entrez Gene ID:4900
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.3 :: 1.2 :: -1.5 :: -1.3 :: -1.1 :: 1.1
KARG Evidence 2
KARG ID:EVIM0466
ORGANISM:human
Entrez Gene ID:4900
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1 :: -1 :: -1.7 :: -3.9 :: -1.9
KARG Evidence 3
KARG ID:QTL0131
ORGANISM:human
Entrez Gene ID:4900
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
64011CBCerebellum43.565323650836953.3739986419678
64011CTXCerebral cortex100.0100.0
64011HIPHippocampal region100.0100.0
64011HPFHippocampal formation100.0100.0
64011HYHypothalamus44.560034751892151.8205816745758
64011LSXLateral septal complex69.962813377380471.1765432357788
64011MBMidbrain63.762437820434671.032751083374
64011MYMedulla27.384071886539530.4188586473465
64011OLFOlfactory bulb95.5203952789307100.0
64011PPons26.204438865184827.5309948921204
64011PALPallidum52.818650245666563.4050097465515
64011RHPRetrohippocampal region100.0100.0
64011sAMYStriatum-like amygdalar nuclei85.777000427246194.6162147521973
64011STRStriatum98.4327030181885100.0
64011STRdStriatum dorsal region100.0100.0
64011STRvStriatum ventral region73.37915039062574.3571548461914
64011THThalamus47.770404338836750.5244418382645
KARG Evidence 4
KARG ID:QTL0131
Trait:Chronic ethanol withdrawal
Peak:17
Peak Marker:D9Mit91
Parents:B6D2F2 (C57BL/6J x DBA/2J)
Evidence ID:11919667
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4900GO:0005516TASFunctioncalmodulin binding
4900GO:0007165TASProcesssignal transduction
4900GO:0007399TASProcessnervous system development
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_006167.1--CalmodulinHPRD03828
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4900NEUG_HUMANQ92686IPR001151GPR6_rcptGPR6 orphan receptor
4900NEUG_HUMANQ92686IPR000048IQ_CaM_bd_regionIQ calmodulin-binding region

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