Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4905
Official Symbol:NSF
Other Aliases:SKD2
See related:HGNC:8016|MIM:601633|HPRD:03380
Chromosome:17
Location:17q21
Gene Description:N-ethylmaleimide-sensitive factor
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0164
ORGANISM:human
Entrez Gene ID:4905
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18195
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0592
ORGANISM:human
Entrez Gene ID:4905
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:60355
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIM0113
ORGANISM:human
Entrez Gene ID:4905
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.59 :: 2.35 :: 5.06 :: 2.92 :: -3.05 :: -2.62 :: -1.26
KARG Evidence 4
KARG ID:EVIM0851
ORGANISM:human
Entrez Gene ID:4905
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.6 :: 1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18195CBCerebellum78.5028076171875100.0
18195CTXCerebral cortex100.0100.0
18195HIPHippocampal region100.0100.0
18195HPFHippocampal formation100.0100.0
18195HYHypothalamus100.0100.0
18195LSXLateral septal complex100.0100.0
18195MBMidbrain100.0100.0
18195MYMedulla80.3552932739258100.0
18195OLFOlfactory bulb100.0100.0
18195PPons91.768310546875100.0
18195PALPallidum100.0100.0
18195RHPRetrohippocampal region100.0100.0
18195sAMYStriatum-like amygdalar nuclei100.0100.0
18195STRStriatum100.0100.0
18195STRdStriatum dorsal region100.0100.0
18195STRvStriatum ventral region100.0100.0
18195THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4905GO:0000166IEAFunctionnucleotide binding
4905GO:0000287IEAFunctionmagnesium ion binding
4905GO:0005524IEAFunctionATP binding
4905GO:0005783IEAComponentendoplasmic reticulum
4905GO:0005795IEAComponentGolgi stack
4905GO:0015031IEAProcessprotein transport
4905GO:0016787IEAFunctionhydrolase activity
4905GO:0017111IEAFunctionnucleoside-triphosphatase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9527AAC39889.1Homo sapiens encoding human GOS28/P28 protein., and translated productsHPRD04936
-8775NP_003818.1N-ethylmaleimide-sensitive factor attachment protein, alphaHPRD04447
-6804NP_004594.1syntaxin 1A (brain)HPRD01721
-6810NP_004595.2syntaxin 4A (placental)HPRD01722
-9482NP_004844.1syntaxin 8HPRD05012
-11337NP_009209.1GABA(A) receptor-associated proteinHPRD05496
-11345NP_009216.1GABA(A) receptor-associated protein-like 2HPRD16246
NP_006169.1--SNAP gamaHPRD03380
NP_006169.1--SNAP receptorHPRD03380
NP_006169.1--GluR2HPRD03380
NP_006169.1--GluR3HPRD03380
NP_006169.1--VAP-AHPRD03380
NP_006169.16804-Syntaxin 1AHPRD03380
NP_006169.19527-GOS28HPRD03380
NP_006169.16810-Syntaxin 4AHPRD03380
NP_006169.18775-SNAP alphaHPRD03380
NP_006169.19482-Syntaxin 8HPRD03380
NP_006169.111337-GABA A receptor associated proteinHPRD03380
NP_006169.18615NP_003706.1vesicle docking protein p115HPRD09135
NP_006169.18615NP_003706.1vesicle docking protein p115HPRD03380
NP_006169.14905NP_006169.1N-ethylmaleimide-sensitive factorHPRD03380
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4905NSF_HUMANP46459IPR003959AAA_ATPase_centrAAA ATPase, central region
4905NSF_HUMANP46459IPR003960AAA_subAAA-protein subdomain
4905NSF_HUMANP46459IPR003338ATPaseVAT_NAAA ATPase VAT, N-terminal
4905NSF_HUMANP46459IPR004201Cdc48_2Cell division protein 48, CDC48, domain 2
4905NSF_HUMANP46459IPR001984Peptidase_S16Peptidase S16, lon protease

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