Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4915
Official Symbol:NTRK2
Other Aliases:GP145-TrkB|TRKB
See related:HGNC:8032|MIM:600456|HPRD:02712
Chromosome:9
Location:9q22.1
Gene Description:neurotrophic tyrosine kinase, receptor, type 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0433
ORGANISM:human
Entrez Gene ID:4915
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25054
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0049
ORGANISM:human
Entrez Gene ID:4915
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-0.29 :: 0.52 :: -0.63 :: -0.32 :: -0.40 :: -0.40 :: -0.43 :: 0.29 :: 0.46 :: -1.00
KARG Evidence 3
KARG ID:EVIM0417
ORGANISM:human
Entrez Gene ID:4915
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.2 :: -1.2 :: -1.2 :: -1.1 :: -2 :: -2.1
KARG Evidence 4
KARG ID:EVIM0485
ORGANISM:human
Entrez Gene ID:4915
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-1.4 :: -1.4 :: 1.1 :: -1.4 :: 1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18212CBCerebellum68.391805648803771.9188613891602
18212CTXCerebral cortex100.0100.0
18212HIPHippocampal region93.226673126220789.8786811828613
18212HPFHippocampal formation98.522525787353592.4781684875488
18212HYHypothalamus87.723171234130977.4392871856689
18212LSXLateral septal complex100.0100.0
18212MBMidbrain71.126461029052765.2970027923584
18212MYMedulla67.542566299438565.3049383163452
18212OLFOlfactory bulb100.0100.0
18212PPons70.804351806640664.6301145553589
18212PALPallidum82.261524200439573.3763027191162
18212RHPRetrohippocampal region100.094.0167961120605
18212sAMYStriatum-like amygdalar nuclei100.097.1584396362305
18212STRStriatum89.880004882812578.8970279693604
18212STRdStriatum dorsal region80.817800521850671.788537979126
18212STRvStriatum ventral region87.571601867675873.7885856628418
18212THThalamus81.353734970092868.6364479064941
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4915GO:0000166IEAFunctionnucleotide binding
4915GO:0004714IEAFunctiontransmembrane receptor protein tyrosine kinase activity
4915GO:0004872IEAFunctionreceptor activity
4915GO:0005524IEAFunctionATP binding
4915GO:0005887TASComponentintegral to plasma membrane
4915GO:0006468IEAProcessprotein amino acid phosphorylation
4915GO:0007169IEAProcesstransmembrane receptor protein tyrosine kinase signaling pathway
4915GO:0007169TASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
4915GO:0007399IEAProcessnervous system development
4915GO:0016020IEAComponentmembrane
4915GO:0016301IEAFunctionkinase activity
4915GO:0016740IEAFunctiontransferase activity
4915GO:0030154IEAProcesscell differentiation
4915GO:0043121TASFunctionneurotrophin binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-25970NP_056318.1SH2 domain-containing putative adapter SH2-BHPRD12336
-57498NP_065789.1kinase D-interacting substance of 220 kDaHPRD17235
NP_006171.2--Truncated TrkB interacting proteinHPRD02712
NP_006171.25770-PTPN1HPRD02712
NP_006171.28440NP_003572.1NCK adaptor protein 2HPRD02712
NP_006171.28440NP_003572.1NCK adaptor protein 2HPRD05378
NP_006171.28655NP_003737.1dynein light chain 1HPRD03334
NP_006171.28655NP_003737.1dynein light chain 1HPRD02712
NP_006171.28878NP_003891.1sequestosome 1HPRD02712
NP_006171.210755NP_005707.1regulator of G-protein signalling 19 interacting protein 1 isoform 1HPRD02712
NP_006171.210755NP_005707.1regulator of G-protein signalling 19 interacting protein 1 isoform 1HPRD05462
NP_006171.253358NP_058544.2src homology 2 domain containing transforming protein C3HPRD12005
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4915IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
4915IPR013098I-setImmunoglobulin I-set
4915IPR007110Ig-likeImmunoglobulin-like
4915IPR001611LRRLeucine-rich repeat
4915IPR000372LRR_cys_NLeucine-rich repeat, cysteine-rich flanking region, N-terminal
4915IPR000719Prot_kinaseProtein kinase
4915IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
4915IPR001245Tyr_pkinaseTyrosine protein kinase
4915IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
4915IPR013695WAKWall-associated kinase
4915NTRK2_HUMANQ16620IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
4915NTRK2_HUMANQ16620IPR013098I-setImmunoglobulin I-set
4915NTRK2_HUMANQ16620IPR007110Ig-likeImmunoglobulin-like
4915NTRK2_HUMANQ16620IPR001611LRRLeucine-rich repeat
4915NTRK2_HUMANQ16620IPR000372LRR_cys_NLeucine-rich repeat, cysteine-rich flanking region, N-terminal
4915NTRK2_HUMANQ16620IPR000719Prot_kinaseProtein kinase
4915NTRK2_HUMANQ16620IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
4915NTRK2_HUMANQ16620IPR001245Tyr_pkinaseTyrosine protein kinase
4915NTRK2_HUMANQ16620IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
4915NTRK2_HUMANQ16620IPR013695WAKWall-associated kinase

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