Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4916
Official Symbol:NTRK3
Other Aliases:TRKC|gp145(trkC)
See related:HGNC:8033|MIM:191316|HPRD:01870
Chromosome:15
Location:15q25
Gene Description:neurotrophic tyrosine kinase, receptor, type 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0605
ORGANISM:human
Entrez Gene ID:4916
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29613
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18213CBCerebellum1.58949124813081.98802489042282
18213CTXCerebral cortex6.59494447708133.25233578681946
18213HIPHippocampal region11.12515878677378.34010934829712
18213HPFHippocampal formation9.517351865768436.24354314804077
18213HYHypothalamus0.5298492759466170.384846448898315
18213LSXLateral septal complex0.6220470368862150.473667912185192
18213MBMidbrain2.748535722494133.08628168702126
18213MYMedulla2.496671915054322.01138520240784
18213OLFOlfactory bulb7.919999837875375.1465744972229
18213PPons1.267104208469391.04608908295631
18213PALPallidum1.154692143201831.25180476903915
18213RHPRetrohippocampal region8.029772281646734.30844581127167
18213sAMYStriatum-like amygdalar nuclei0.1785512641072270.136297281831503
18213STRStriatum1.030506491661070.694101423025131
18213STRdStriatum dorsal region1.218403309583660.723627820611
18213STRvStriatum ventral region0.9706577435135840.97185479849577
18213THThalamus0.8014415055513380.578695058822632
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4916GO:0000166IEAFunctionnucleotide binding
4916GO:0004674IEAFunctionprotein serine/threonine kinase activity
4916GO:0004713IEAFunctionprotein-tyrosine kinase activity
4916GO:0004714IEAFunctiontransmembrane receptor protein tyrosine kinase activity
4916GO:0004872IEAFunctionreceptor activity
4916GO:0005524IEAFunctionATP binding
4916GO:0005887TASComponentintegral to plasma membrane
4916GO:0006468IEAProcessprotein amino acid phosphorylation
4916GO:0007169IEAProcesstransmembrane receptor protein tyrosine kinase signaling pathway
4916GO:0007169TASProcesstransmembrane receptor protein tyrosine kinase signaling pathway
4916GO:0007399IEAProcessnervous system development
4916GO:0016020IEAComponentmembrane
4916GO:0016301IEAFunctionkinase activity
4916GO:0016740IEAFunctiontransferase activity
4916GO:0030154IEAProcesscell differentiation
4916GO:0043121TASFunctionneurotrophin binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-27018NP_055195.1nerve growth factor receptor (TNFRSF16) associated protein 1 isoform bHPRD02291
-57498NP_065789.1kinase D-interacting substance of 220 kDaHPRD17235
NP_002521.127018-NGFR associated protein 1HPRD01870
NP_002521.15335NP_002651.1phospholipase C, gamma 1 (formerly subtype 148)HPRD01870
NP_002521.15335NP_002651.2phospholipase C gamma 1 isoform aHPRD01398
NP_002521.15770NP_002818.1protein tyrosine phosphatase, non-receptor type 1HPRD01870
NP_002521.18878NP_003891.1sequestosome 1HPRD01870
NP_002521.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD01870
NP_002521.16464NP_892113.1SHC (Src homology 2 domain containing) transforming protein 1HPRD02780
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4916IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
4916IPR013098I-setImmunoglobulin I-set
4916IPR007110Ig-likeImmunoglobulin-like
4916IPR013151ImmunoglobulinImmunoglobulin
4916IPR001611LRRLeucine-rich repeat
4916IPR000372LRR_cys_NLeucine-rich repeat, cysteine-rich flanking region, N-terminal
4916IPR000719Prot_kinaseProtein kinase
4916IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
4916IPR001245Tyr_pkinaseTyrosine protein kinase
4916IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
4916IPR013695WAKWall-associated kinase
4916NTRK3_HUMANQ16288IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
4916NTRK3_HUMANQ16288IPR013098I-setImmunoglobulin I-set
4916NTRK3_HUMANQ16288IPR007110Ig-likeImmunoglobulin-like
4916NTRK3_HUMANQ16288IPR013151ImmunoglobulinImmunoglobulin
4916NTRK3_HUMANQ16288IPR001611LRRLeucine-rich repeat
4916NTRK3_HUMANQ16288IPR000372LRR_cys_NLeucine-rich repeat, cysteine-rich flanking region, N-terminal
4916NTRK3_HUMANQ16288IPR000719Prot_kinaseProtein kinase
4916NTRK3_HUMANQ16288IPR002011RecepttyrkinsIIReceptor tyrosine kinase, class II
4916NTRK3_HUMANQ16288IPR001245Tyr_pkinaseTyrosine protein kinase
4916NTRK3_HUMANQ16288IPR008266Tyr_pkinase_ASTyrosine protein kinase, active site
4916NTRK3_HUMANQ16288IPR013695WAKWall-associated kinase

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