Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4923
Official Symbol:NTSR1
Other Aliases:NTR
See related:HGNC:8039|MIM:162651|HPRD:01218
Chromosome:20
Location:20q13-20q13
Gene Description:neurotensin receptor 1 (high affinity)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:QTL0059
ORGANISM:human
Entrez Gene ID:4923
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0060
ORGANISM:human
Entrez Gene ID:4923
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:QTL0061
ORGANISM:human
Entrez Gene ID:4923
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18216CBCerebellum2.45116377249363.16110024228692
18216CTXCerebral cortex3.517294965684412.80637397989631
18216HIPHippocampal region2.652541003189983.08366876468062
18216HPFHippocampal formation6.293356306850916.75373939424753
18216HYHypothalamus0.801833577454090.784140825271606
18216LSXLateral septal complex0.8996352553367610.779090225696564
18216MBMidbrain2.686950504779824.32384127378464
18216MYMedulla1.523506689816712.02075879275799
18216OLFOlfactory bulb4.872768301516773.9978441670537
18216PPons0.6925099194049840.873318716883659
18216PALPallidum1.27003980427981.64905386418104
18216RHPRetrohippocampal region13.742816843092413.0977185443044
18216sAMYStriatum-like amygdalar nuclei1.103011131286621.15967889875174
18216STRStriatum1.083224989473821.13529049605131
18216STRdStriatum dorsal region1.215563811361791.33945790678263
18216STRvStriatum ventral region0.7336623184382920.672876801341772
18216THThalamus0.6332772485911850.664513977244496
KARG Evidence 4
KARG ID:QTL0059
Trait:alcohol preference locus, female specific
Peak:107
Peak Marker:D2Mit74
Parents:recombinant Inbreds(RI) AXB and BXA
Evidence ID:9880655
KARG Evidence 5
KARG ID:QTL0060
Trait:alcohol preference locus, male specific
Peak:107
Peak Marker:D2Mit74
Parents:recombinant Inbreds(RI) AXB and BXA
Evidence ID:9880655
KARG Evidence 6
KARG ID:QTL0061
Trait:alcohol consumption
Peak:107
Peak Marker:D2Mit74
Parents:C57BL/6ByJ x BALB/c intercross
Evidence ID:11109025
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4923GO:0001584IEAFunctionrhodopsin-like receptor activity
4923GO:0004872IEAFunctionreceptor activity
4923GO:0005783TASComponentendoplasmic reticulum
4923GO:0005794TASComponentGolgi apparatus
4923GO:0005887TASComponentintegral to plasma membrane
4923GO:0007165IEAProcesssignal transduction
4923GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
4923GO:0007268TASProcesssynaptic transmission
4923GO:0016020IEAComponentmembrane
4923GO:0016492IEAFunctionneurotensin receptor activity, G-protein coupled
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7189NP_665802.1TNF receptor-associated factor 6HPRD03833
NP_002522.17189-TRAF6HPRD01218
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4923NTR1_HUMANP30989IPR003905GHS1_rcptGrowth hormone secretagogue receptor, type 1
4923NTR1_HUMANP30989IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
4923NTR1_HUMANP30989IPR003985NT1_rcptNeurotensin type 1 receptor
4923NTR1_HUMANP30989IPR003984NT_rcptNeurotensin receptor
4923NTR1_HUMANP30989IPR002286P2_purnocptorP2 purinoceptor

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