Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4929
Official Symbol:NR4A2
Other Aliases:HZF-3|NOT|NURR1|RNR1|TINUR
See related:HGNC:7981|MIM:601828|HPRD:03493
Chromosome:2
Location:2q22-q23
Gene Description:nuclear receptor subfamily 4, group A, member 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0237
ORGANISM:human
Entrez Gene ID:4929
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18227
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18227CBCerebellum100.091.6476707458496
18227CTXCerebral cortex97.315429687579.1603813171387
18227HIPHippocampal region85.597106933593886.8706932067871
18227HPFHippocampal formation99.8201370239258100.0
18227HYHypothalamus86.694412231445374.0570869445801
18227LSXLateral septal complex95.961544036865246.7277889251709
18227MBMidbrain83.482547760009866.5800533294678
18227MYMedulla81.702550888061580.5066547393799
18227OLFOlfactory bulb100.0100.0
18227PPons76.796491622924874.2737846374512
18227PALPallidum88.406932830810567.1115894317627
18227RHPRetrohippocampal region100.0100.0
18227sAMYStriatum-like amygdalar nuclei100.068.2727947235107
18227STRStriatum88.081737518310559.3689270019531
18227STRdStriatum dorsal region78.838424682617251.2645301818848
18227STRvStriatum ventral region100.079.1606788635254
18227THThalamus81.710836410522571.1098575592041
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4929GO:0003700IEAFunctiontranscription factor activity
4929GO:0003707IEAFunctionsteroid hormone receptor activity
4929GO:0004879IEAFunctionligand-dependent nuclear receptor activity
4929GO:0005634IEAComponentnucleus
4929GO:0005634TASComponentnucleus
4929GO:0006350IEAProcesstranscription
4929GO:0006355IEAProcessregulation of transcription, DNA-dependent
4929GO:0007165NASProcesssignal transduction
4929GO:0008270IEAFunctionzinc ion binding
4929GO:0019735TASProcessantimicrobial humoral response (sensu Vertebrata)
4929GO:0043565IEAFunctionsequence-specific DNA binding
4929GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-6256NP_002948.1retinoid X receptor, alphaHPRD01577
-6257NP_068811.1retinoid X receptor, betaHPRD01578
NP_006177.16256-Retinoid X receptor, alphaHPRD03493
NP_006177.16257-Retinoid X receptor, betaHPRD03493
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4929NR4A2_HUMANP43354IPR000536Hrmn_rcpt_lig_bdNuclear hormone receptor, ligand-binding
4929NR4A2_HUMANP43354IPR001628Hrmn_rcpt_DNA_bdNuclear hormone receptor, DNA-binding
4929NR4A2_HUMANP43354IPR003072NOR1_rcptOrphan nuclear receptor, NOR1 type
4929NR4A2_HUMANP43354IPR003070Nuc_orph_rcptOrphan nuclear receptor
4929NR4A2_HUMANP43354IPR003073NURR_rcptOrphan nuclear receptor, NURR type
4929NR4A2_HUMANP43354IPR003078Rtnoid_rcptRetinoic acid receptor
4929NR4A2_HUMANP43354IPR001723Str_hrmn_rcptSteroid hormone receptor
4929NR4A2_HUMANP43354IPR000324VitD_rcptVitamin D receptor
4929NR4A2_HUMANP43354IPR013629Znf-C4_CZinc finger, C4-type, C-terminal

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