Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4986
Official Symbol:OPRK1
Other Aliases:KOR|OPRK
See related:HGNC:8154|MIM:165196|HPRD:01309
Chromosome:8
Location:8q11.2
Gene Description:opioid receptor, kappa 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0052
ORGANISM:human
Entrez Gene ID:4986
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18387
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0031
ORGANISM:human
Entrez Gene ID:4986
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9862779
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ADMINISTRATION
Addiction Brain Area:Nucleus Accumbens
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0144
ORGANISM:human
Entrez Gene ID:4986
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15608558
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIATE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVID0014
ORGANISM:human
Entrez Gene ID:4986
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:165196
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18387CBCerebellum0.8647621870040891.33896243572235
18387CTXCerebral cortex1.535695433616641.71920800209045
18387HIPHippocampal region0.7787353992462160.892545163631439
18387HPFHippocampal formation0.6615633964538570.738884270191193
18387HYHypothalamus0.1154464781284330.0976928472518921
18387LSXLateral septal complex0.1220921203494070.0896782130002975
18387MBMidbrain0.414012193679810.724108517169952
18387MYMedulla0.6087085604667660.853757560253143
18387OLFOlfactory bulb2.148977756500243.06399011611938
18387PPons0.3360514044761660.48721319437027
18387PALPallidum0.4246865808963780.509912729263306
18387RHPRetrohippocampal region0.402796953916550.457256644964218
18387sAMYStriatum-like amygdalar nuclei0.2915650010108950.28682354092598
18387STRStriatum1.33060061931610.999055206775665
18387STRdStriatum dorsal region1.598347783088681.24376595020294
18387STRvStriatum ventral region1.366219282150270.847620666027069
18387THThalamus0.4754558205604550.728843867778778
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4986GO:0001584IEAFunctionrhodopsin-like receptor activity
4986GO:0004872IEAFunctionreceptor activity
4986GO:0004987TASFunctionkappa-opioid receptor activity
4986GO:0005887TASComponentintegral to plasma membrane
4986GO:0006955TASProcessimmune response
4986GO:0007165IEAProcesssignal transduction
4986GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
4986GO:0007193TASProcessG-protein signaling, adenylate cyclase inhibiting pathway
4986GO:0007268TASProcesssynaptic transmission
4986GO:0007600TASProcesssensory perception
4986GO:0007610TASProcessbehavior
4986GO:0016020IEAComponentmembrane
4986GO:0019079TASProcessviral genome replication
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000903.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
NP_000903.19368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
NP_000903.2---BIND262453
NP_000903.2---BIND262451
NP_000903.2---BIND262452
NP_000903.29737NP_055525.1G protein-coupled receptor associated sorting protein 1BIND177244
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4986OPRK_HUMANP41145IPR000248Angtn2_rcptAngiotensin II receptor
4986OPRK_HUMANP41145IPR000355Chmkine_rcptChemokine receptor
4986OPRK_HUMANP41145IPR000405Galanin_rcptGalanin receptor
4986OPRK_HUMANP41145IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
4986OPRK_HUMANP41145IPR000452Kappa_opi_rcptKappa opioid receptor
4986OPRK_HUMANP41145IPR009150Neuropept_W_rcptNeuropeptide W receptor
4986OPRK_HUMANP41145IPR000611NPY_rcptNeuropeptide Y receptor
4986OPRK_HUMANP41145IPR001418Opioid_rcptOpioid receptor
4986OPRK_HUMANP41145IPR002286P2_purnocptorP2 purinoceptor
4986OPRK_HUMANP41145IPR000586Somatstn_rcptSomatostatin receptor

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