Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4987
Official Symbol:OPRL1
Other Aliases:KOR-3|MGC34578|NOCIR|OOR|ORL1
See related:HGNC:8155|MIM:602548|HPRD:03971
Chromosome:20
Location:20q13.33
Gene Description:opiate receptor-like 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0174
ORGANISM:human
Entrez Gene ID:4987
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18389
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4987GO:0001584IEAFunctionrhodopsin-like receptor activity
4987GO:0004872IEAFunctionreceptor activity
4987GO:0005887TASComponentintegral to plasma membrane
4987GO:0007165IEAProcesssignal transduction
4987GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
4987GO:0007193TASProcessG-protein signaling, adenylate cyclase inhibiting pathway
4987GO:0007204IGIProcesselevation of cytosolic calcium ion concentration
4987GO:0007600TASProcesssensory perception
4987GO:0015051IEAFunctionX-opioid receptor activity
4987GO:0016020IEAComponentmembrane
4987GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9630NP_004288.1guanine nucleotide binding protein (G protein), alpha 14HPRD05095
-10287NP_005864.1G protein signalling regulator 19HPRD05461
-5368NP_006219.1prepronociceptinHPRD03268
NP_000904.19630-G protein alpha subunit 14HPRD03971
NP_000904.15368-NociceptinHPRD03971
NP_000904.110287-Regulator of G protein signaling 19HPRD03971
NP_872588.19737NP_055525.1G protein-coupled receptor associated sorting protein 1BIND177237
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4987OPRX_HUMANP41146IPR000405Galanin_rcptGalanin receptor
4987OPRX_HUMANP41146IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
4987OPRX_HUMANP41146IPR008103KiSS_1_rcptKiSS-1 peptide receptor
4987OPRX_HUMANP41146IPR009150Neuropept_W_rcptNeuropeptide W receptor
4987OPRX_HUMANP41146IPR000611NPY_rcptNeuropeptide Y receptor
4987OPRX_HUMANP41146IPR001418Opioid_rcptOpioid receptor
4987OPRX_HUMANP41146IPR002286P2_purnocptorP2 purinoceptor
4987OPRX_HUMANP41146IPR000586Somatstn_rcptSomatostatin receptor
4987OPRX_HUMANP41146IPR001420X_opioid_rcptX opioid receptor

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