Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:4988
Official Symbol:OPRM1
Other Aliases:KIAA0403|MOR1|OPRM
See related:HGNC:8156|MIM:600018|HPRD:02484
Chromosome:6
Location:6q24-q25
Gene Description:opioid receptor, mu 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0008
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18390
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIL0023
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9689128
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIATE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0063
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:11933204
Addiction Drug:OPIOIDS
Addiction Drug Detail:HEROIN ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0095
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:12898579
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIOID ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:EVIL0137
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:15542732
Addiction Drug:METHAMPHETAMINE
Addiction Drug Detail:METHAMPHETAMINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 6
KARG ID:EVIL0218
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16402083
Addiction Drug:METHAMPHETAMINE
Addiction Drug Detail:METHAMPHETAMINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 7
KARG ID:EVIL0222
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16415919
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIOID ABUSE
Addiction Brain Area:plasma concentrations
Drug Effects:
Fold Change:
KARG Evidence 8
KARG ID:EVID0017
ORGANISM:human
Entrez Gene ID:4988
Evidence Type:Database Annotations
Evidence ID Type:OMIM
Evidence ID:MIM:600018
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18390CBCerebellum2.275266408920292.69794154167175
18390CTXCerebral cortex1.521678805351261.22073578834534
18390HIPHippocampal region2.704657077789312.98676919937134
18390HPFHippocampal formation2.598824024200442.73827743530273
18390HYHypothalamus0.7041820287704470.691964745521545
18390LSXLateral septal complex0.4627743661403660.375391960144043
18390MBMidbrain2.409751415252692.76619434356689
18390MYMedulla5.025669574737555.15861988067627
18390OLFOlfactory bulb2.525296926498413.063321352005
18390PPons5.43989801406865.19471740722656
18390PALPallidum0.9058083891868590.756137132644653
18390RHPRetrohippocampal region2.510986804962162.41742968559265
18390sAMYStriatum-like amygdalar nuclei2.055413246154791.34505999088287
18390STRStriatum0.9529915452003480.755458891391754
18390STRdStriatum dorsal region0.9131911396980290.812912940979004
18390STRvStriatum ventral region0.4826964437961580.302292972803116
18390THThalamus2.305396080017092.16151261329651
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
4988GO:0001584IEAFunctionrhodopsin-like receptor activity
4988GO:0004872IEAFunctionreceptor activity
4988GO:0004988IEAFunctionmu-opioid receptor activity
4988GO:0004988TASFunctionmu-opioid receptor activity
4988GO:0005783TASComponentendoplasmic reticulum
4988GO:0005794TASComponentGolgi apparatus
4988GO:0005886TASComponentplasma membrane
4988GO:0005887TASComponentintegral to plasma membrane
4988GO:0007165IEAProcesssignal transduction
4988GO:0007186IEAProcessG-protein coupled receptor protein signaling pathway
4988GO:0007187TASProcessG-protein signaling, coupled to cyclic nucleotide second messenger
4988GO:0007600TASProcesssensory perception
4988GO:0007610TASProcessbehavior
4988GO:0008285TASProcessnegative regulation of cell proliferation
4988GO:0016020IEAComponentmembrane
4988GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9737NP_055525.1G protein-coupled receptor associated sorting protein 1HPRD02333
AAB60354.1---BIND194789
NP_000905.19737-G protein coupled receptor associated sorting proteinHPRD02484
NP_000905.15338NP_002654.2phospholipase D2HPRD03857
NP_000905.15338NP_002654.2phospholipase D2HPRD02484
NP_000905.19737NP_055525.1G protein-coupled receptor associated sorting protein 1BIND177238
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
4988IPR000355Chmkine_rcptChemokine receptor
4988IPR000826Frt_met_rcptFormyl/methionyl peptide receptor
4988IPR000405Galanin_rcptGalanin receptor
4988IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
4988IPR000105Mu_opioid_rcptMu opioid receptor
4988IPR009150Neuropept_W_rcptNeuropeptide W receptor
4988IPR000611NPY_rcptNeuropeptide Y receptor
4988IPR001418Opioid_rcptOpioid receptor
4988IPR002286P2_purnocptorP2 purinoceptor
4988IPR000586Somatstn_rcptSomatostatin receptor
4988OPRM_HUMANP35372IPR000355Chmkine_rcptChemokine receptor
4988OPRM_HUMANP35372IPR000826Frt_met_rcptFormyl/methionyl peptide receptor
4988OPRM_HUMANP35372IPR000405Galanin_rcptGalanin receptor
4988OPRM_HUMANP35372IPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamily
4988OPRM_HUMANP35372IPR000105Mu_opioid_rcptMu opioid receptor
4988OPRM_HUMANP35372IPR009150Neuropept_W_rcptNeuropeptide W receptor
4988OPRM_HUMANP35372IPR000611NPY_rcptNeuropeptide Y receptor
4988OPRM_HUMANP35372IPR001418Opioid_rcptOpioid receptor
4988OPRM_HUMANP35372IPR002286P2_purnocptorP2 purinoceptor
4988OPRM_HUMANP35372IPR000586Somatstn_rcptSomatostatin receptor

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