Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5033
Official Symbol:P4HA1
Other Aliases:4-PH alpha-1|P4HA
See related:HGNC:8546|MIM:176710|HPRD:08901
Chromosome:10
Location:10q21.3-q23.1
Gene Description:procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0488
ORGANISM:human
Entrez Gene ID:5033
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:64475
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18451CBCerebellum14.513086318969716.3217792510986
18451CTXCerebral cortex93.306900024414172.0930252075195
18451HIPHippocampal region56.251903533935591.7205429077148
18451HPFHippocampal formation58.474700927734474.5015869140625
18451HYHypothalamus24.674160003662119.5097923278809
18451LSXLateral septal complex41.44542694091832.0937576293945
18451MBMidbrain15.078912734985413.0016794204712
18451MYMedulla16.594738006591817.3359127044678
18451OLFOlfactory bulb56.992176055908248.6416397094727
18451PPons14.672997474670413.6844921112061
18451PALPallidum22.083679199218818.5098819732666
18451RHPRetrohippocampal region62.726482391357452.162239074707
18451sAMYStriatum-like amygdalar nuclei37.017181396484426.7266731262207
18451STRStriatum91.018753051757875.502685546875
18451STRdStriatum dorsal region100.0100.0
18451STRvStriatum ventral region60.728332519531243.6048583984375
18451THThalamus32.334159851074226.7033824920654
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5033GO:0004656TASFunctionprocollagen-proline 4-dioxygenase activity
5033GO:0005488IEAFunctionbinding
5033GO:0005506IEAFunctioniron ion binding
5033GO:0005783TASComponentendoplasmic reticulum
5033GO:0016491IEAFunctionoxidoreductase activity
5033GO:0016702IEAFunctionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
5033GO:0016706IEAFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
5033GO:0019538IEAProcessprotein metabolism
5033GO:0031418IEAFunctionL-ascorbic acid binding
5033GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5033IPR0051232OG-FeII_Oase2OG-Fe(II) oxygenase
5033IPR013547Pro_4_hyd_alph_NProlyl 4-hydroxylase alpha-subunit, N-terminal
5033IPR013105TPR_2Tetratricopeptide TPR_2
5033IPR013026TPR_regionTetratricopeptide region
5033P4HA1_HUMANP13674IPR0051232OG-FeII_Oase2OG-Fe(II) oxygenase
5033P4HA1_HUMANP13674IPR013547Pro_4_hyd_alph_NProlyl 4-hydroxylase alpha-subunit, N-terminal
5033P4HA1_HUMANP13674IPR013105TPR_2Tetratricopeptide TPR_2
5033P4HA1_HUMANP13674IPR013026TPR_regionTetratricopeptide region

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