Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5046
Official Symbol:PCSK6
Other Aliases:PACE4|SPC4
See related:HGNC:8569|MIM:167405|HPRD:01329
Chromosome:15
Location:15q26.3
Gene Description:proprotein convertase subtilisin/kexin type 6
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0843
ORGANISM:human
Entrez Gene ID:5046
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.9 :: -2.1
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18553CBCerebellum24.1331996917725100.0
18553CTXCerebral cortex3.142977833747861.87824285030365
18553HIPHippocampal region2.380689859390261.9064114689827
18553HPFHippocampal formation2.169864296913151.44656592607498
18553HYHypothalamus3.10097157955171.99449759721756
18553LSXLateral septal complex6.119644403457643.60525417327881
18553MBMidbrain5.302817821502694.95165967941284
18553MYMedulla14.779074192047111.3435134887695
18553OLFOlfactory bulb11.01719760894787.28348755836487
18553PPons15.309278488159210.0896797180176
18553PALPallidum3.203639149665831.81546127796173
18553RHPRetrohippocampal region1.887545347213750.866871148347855
18553sAMYStriatum-like amygdalar nuclei12.1480245590217.81589365005493
18553STRStriatum5.334275007247923.09398078918457
18553STRdStriatum dorsal region4.871347188949582.90132713317871
18553STRvStriatum ventral region3.497676730155941.53750836849213
18553THThalamus5.212022781372073.43318867683411
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5046GO:0004289TASFunctionsubtilase activity
5046GO:0005509IEAFunctioncalcium ion binding
5046GO:0005783IEAComponentendoplasmic reticulum
5046GO:0006508TASProcessproteolysis
5046GO:0007267TASProcesscell-cell signaling
5046GO:0008233IEAFunctionpeptidase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5046IPR000209Pept_S8_S53Peptidase S8 and S53, subtilisin, kexin, sedolisin
5046IPR002884PrprotnconvertsPProprotein convertase, P
5046IPR007087Znf_C2H2Zinc finger, C2H2-type
5046PCSK6_HUMANP29122IPR000209Pept_S8_S53Peptidase S8 and S53, subtilisin, kexin, sedolisin
5046PCSK6_HUMANP29122IPR010909PLACPLAC
5046PCSK6_HUMANP29122IPR002884PrprotnconvertsPProprotein convertase, P
5046PCSK6_HUMANP29122IPR007087Znf_C2H2Zinc finger, C2H2-type

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