Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5048
Official Symbol:PAFAH1B1
Other Aliases:LIS1|LIS2|MDCR|PAFAH
See related:HGNC:8574|MIM:601545|HPRD:03329
Chromosome:17
Location:17p13.3
Gene Description:platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0868
ORGANISM:human
Entrez Gene ID:5048
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18472CBCerebellum100.0100.0
18472CTXCerebral cortex100.0100.0
18472HIPHippocampal region100.0100.0
18472HPFHippocampal formation100.0100.0
18472HYHypothalamus100.0100.0
18472LSXLateral septal complex100.0100.0
18472MBMidbrain100.0100.0
18472MYMedulla100.0100.0
18472OLFOlfactory bulb100.0100.0
18472PPons100.0100.0
18472PALPallidum100.0100.0
18472RHPRetrohippocampal region100.0100.0
18472sAMYStriatum-like amygdalar nuclei100.0100.0
18472STRStriatum100.0100.0
18472STRdStriatum dorsal region100.0100.0
18472STRvStriatum ventral region100.0100.0
18472THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5048GO:0000132IMPProcessestablishment of mitotic spindle orientation
5048GO:0000235IDAComponentastral microtubule
5048GO:0000776IDAComponentkinetochore
5048GO:0005635IDAComponentnuclear envelope
5048GO:0005856IEAComponentcytoskeleton
5048GO:0005874IEAComponentmicrotubule
5048GO:0005875IDAComponentmicrotubule associated complex
5048GO:0005938IDAComponentcell cortex
5048GO:0006629TASProcesslipid metabolism
5048GO:0006928TASProcesscell motility
5048GO:0007017IDAProcessmicrotubule-based process
5048GO:0007049IEAProcesscell cycle
5048GO:0007067IEAProcessmitosis
5048GO:0007165TASProcesssignal transduction
5048GO:0007399TASProcessnervous system development
5048GO:0030154IEAProcesscell differentiation
5048GO:0045502IDAFunctiondynein binding
5048GO:0051301IEAProcesscell division
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5049NP_002563.1platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDaHPRD03940
-5050NP_002564.1platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDaHPRD04354
-6249NP_002947.1restin isoform aHPRD01568
-10726NP_006591.1nuclear distribution gene C homolog (A. nidulans)HPRD10122
-27019NP_036276.1dynein, axonemal, intermediate polypeptide 1HPRD05080
-54820NP_060138.1nuclear distribution gene E homolog 1HPRD14815
NP_000421.1--TubulinHPRD03329
NP_000421.1--NudCHPRD03329
NP_000421.1--NudEHPRD03329
NP_000421.1--Dynein heavy chainHPRD03329
NP_000421.15049-PAFAH beta subunitHPRD03329
NP_000421.15050-Platelet activating factor acetylhydrolase isoform 1B gamma subunitHPRD03329
NP_000421.127019-Axonemal dynein intermediate chain 1HPRD03329
NP_000421.16249-RestinHPRD03329
NP_000421.15048NP_000421.1platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD)HPRD03329
NP_000421.110808NP_006635.2heat shock 105kDHPRD03329
NP_000421.110808NP_006635.2heat shock 105kDHPRD09990
NP_000421.181565NP_110435.1nudE nuclear distribution gene E homolog like 1 (A. nidulans) isoform BHPRD03329
NP_000421.181565NP_110435.1nudE nuclear distribution gene E homolog like 1 (A. nidulans) isoform BHPRD06340
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5048LIS1_HUMANP43034IPR006594LisHLissencephaly type-1-like homology motif
5048LIS1_HUMANP43034IPR013720LisH-PF08513LisH
5048LIS1_HUMANP43034IPR013577LLGL2Lethal giant larvae homologue 2
5048LIS1_HUMANP43034IPR001680WD40WD-40 repeat

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.