Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:506
Official Symbol:ATP5B
Other Aliases:ATPMB|ATPSB|MGC5231
See related:HGNC:830|MIM:102910|HPRD:00044
Chromosome:12
Location:12q13.13
Gene Description:ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0015
ORGANISM:human
Entrez Gene ID:506
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:11947
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0384
ORGANISM:human
Entrez Gene ID:506
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:171374
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11947CBCerebellum100.0100.0
11947CTXCerebral cortex100.0100.0
11947HIPHippocampal region100.0100.0
11947HPFHippocampal formation100.0100.0
11947HYHypothalamus100.0100.0
11947LSXLateral septal complex100.0100.0
11947MBMidbrain100.0100.0
11947MYMedulla100.0100.0
11947OLFOlfactory bulb100.0100.0
11947PPons100.0100.0
11947PALPallidum100.0100.0
11947RHPRetrohippocampal region100.0100.0
11947sAMYStriatum-like amygdalar nuclei100.0100.0
11947STRStriatum100.0100.0
11947STRdStriatum dorsal region100.0100.0
11947STRvStriatum ventral region100.0100.0
11947THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
506GO:0000166IEAFunctionnucleotide binding
506GO:0005215NASFunctiontransporter activity
506GO:0005515IPIFunctionprotein binding
506GO:0005524IEAFunctionATP binding
506GO:0005739IEAComponentmitochondrion
506GO:0005753TASComponentproton-transporting ATP synthase complex (sensu Eukaryota)
506GO:0005754TASComponentproton-transporting ATP synthase, catalytic core (sensu Eukaryota)
506GO:0006091NRProcessgeneration of precursor metabolites and energy
506GO:0006811IEAProcession transport
506GO:0008553IEAFunctionhydrogen-exporting ATPase activity, phosphorylative mechanism
506GO:0015986IEAProcessATP synthesis coupled proton transport
506GO:0015992IEAProcessproton transport
506GO:0016787IEAFunctionhydrolase activity
506GO:0017111IEAFunctionnucleoside-triphosphatase activity
506GO:0045261IEAComponentproton-transporting ATP synthase complex, catalytic core F(1)
506GO:0046872IEAFunctionmetal ion binding
506GO:0046933IEAFunctionhydrogen-transporting ATP synthase activity, rotational mechanism
506GO:0046961IEAFunctionhydrogen-transporting ATPase activity, rotational mechanism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_001677.2--Apolipoprotein A-IHPRD00044
NP_001677.25340NP_000292.1plasminogenHPRD00044
NP_001677.264756NP_073582.1ATP synthase mitochondrial F1 complex assembly factor 1HPRD12332
NP_001677.291647NP_663729.1ATP synthase mitochondrial F1 complex assembly factor 2HPRD10599
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
506ATPB_HUMANP06576IPR000194ATPase_a_b_nl-bdATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
506ATPB_HUMANP06576IPR000793ATPase_a_b_CATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
506ATPB_HUMANP06576IPR004100ATPase_a_b_NATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal
506ATPB_HUMANP06576IPR003928Claudin18Claudin-18

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