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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 506 Official Symbol: ATP5B Other Aliases: ATPMB|ATPSB|MGC5231 See related: HGNC:830|MIM:102910|HPRD:00044 Chromosome: 12 Location: 12q13.13 Gene Description: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIC0015 ORGANISM: human Entrez Gene ID: 506 Evidence Type: Mapping from mouse Evidence ID Type: Entrez Gene Evidence ID: 11947 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: KARG Evidence 2 KARG ID: EVIC0384 ORGANISM: human Entrez Gene ID: 506 Evidence Type: Mapping from rat Evidence ID Type: Entrez Gene Evidence ID: 171374 Addiction Drug: Addiction Drug Detail: Addiction Brain Area: Drug Effects: Fold Change: Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 11947 CB Cerebellum 100.0 100.0 11947 CTX Cerebral cortex 100.0 100.0 11947 HIP Hippocampal region 100.0 100.0 11947 HPF Hippocampal formation 100.0 100.0 11947 HY Hypothalamus 100.0 100.0 11947 LSX Lateral septal complex 100.0 100.0 11947 MB Midbrain 100.0 100.0 11947 MY Medulla 100.0 100.0 11947 OLF Olfactory bulb 100.0 100.0 11947 P Pons 100.0 100.0 11947 PAL Pallidum 100.0 100.0 11947 RHP Retrohippocampal region 100.0 100.0 11947 sAMY Striatum-like amygdalar nuclei 100.0 100.0 11947 STR Striatum 100.0 100.0 11947 STRd Striatum dorsal region 100.0 100.0 11947 STRv Striatum ventral region 100.0 100.0 11947 TH Thalamus 100.0 100.0 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 506 GO:0000166 IEA Function nucleotide binding 506 GO:0005215 NAS Function transporter activity 506 GO:0005515 IPI Function protein binding 506 GO:0005524 IEA Function ATP binding 506 GO:0005739 IEA Component mitochondrion 506 GO:0005753 TAS Component proton-transporting ATP synthase complex (sensu Eukaryota) 506 GO:0005754 TAS Component proton-transporting ATP synthase, catalytic core (sensu Eukaryota) 506 GO:0006091 NR Process generation of precursor metabolites and energy 506 GO:0006811 IEA Process ion transport 506 GO:0008553 IEA Function hydrogen-exporting ATPase activity, phosphorylative mechanism 506 GO:0015986 IEA Process ATP synthesis coupled proton transport 506 GO:0015992 IEA Process proton transport 506 GO:0016787 IEA Function hydrolase activity 506 GO:0017111 IEA Function nucleoside-triphosphatase activity 506 GO:0045261 IEA Component proton-transporting ATP synthase complex, catalytic core F(1) 506 GO:0046872 IEA Function metal ion binding 506 GO:0046933 IEA Function hydrogen-transporting ATP synthase activity, rotational mechanism 506 GO:0046961 IEA Function hydrogen-transporting ATPase activity, rotational mechanism Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID NP_001677.2 - - Apolipoprotein A-I HPRD 00044 NP_001677.2 5340 NP_000292.1 plasminogen HPRD 00044 NP_001677.2 64756 NP_073582.1 ATP synthase mitochondrial F1 complex assembly factor 1 HPRD 12332 NP_001677.2 91647 NP_663729.1 ATP synthase mitochondrial F1 complex assembly factor 2 HPRD 10599 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 506 ATPB_HUMAN P06576 IPR000194 ATPase_a_b_nl-bd ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding 506 ATPB_HUMAN P06576 IPR000793 ATPase_a_b_C ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal 506 ATPB_HUMAN P06576 IPR004100 ATPase_a_b_N ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal 506 ATPB_HUMAN P06576 IPR003928 Claudin18 Claudin-18 © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.