Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5063
Official Symbol:PAK3
Other Aliases:CDKN1A|MRX30|MRX47|OPHN3|PAK3beta|bPAK|hPAK3
See related:HGNC:8592|MIM:300142|HPRD:02142
Chromosome:X
Location:Xq22.3-q23
Gene Description:p21 (CDKN1A)-activated kinase 3
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0128
ORGANISM:human
Entrez Gene ID:5063
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18481
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18481CBCerebellum9.8019804358482412.1262809634209
18481CTXCerebral cortex57.025937080383355.2412052154541
18481HIPHippocampal region59.735754966735864.2999458312988
18481HPFHippocampal formation65.055412292480566.199291229248
18481HYHypothalamus69.781015396118268.4863567352295
18481LSXLateral septal complex68.706945419311565.8780384063721
18481MBMidbrain47.100888729095553.6620845794678
18481MYMedulla39.397123813629255.7749719619751
18481OLFOlfactory bulb57.255345344543558.4362859725952
18481PPons39.773312568664651.4213037490845
18481PALPallidum54.163041114807163.4857950210571
18481RHPRetrohippocampal region74.540267944335971.5178565979004
18481sAMYStriatum-like amygdalar nuclei87.315834045410283.8698081970215
18481STRStriatum36.810534477233935.4944000244141
18481STRdStriatum dorsal region18.969788789749117.3999934196472
18481STRvStriatum ventral region43.748904228210434.8630657196045
18481THThalamus37.528513908386237.9577651023865
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5063GO:0000166IEAFunctionnucleotide binding
5063GO:0000287IEAFunctionmagnesium ion binding
5063GO:0004674IEAFunctionprotein serine/threonine kinase activity
5063GO:0005524IEAFunctionATP binding
5063GO:0006468IEAProcessprotein amino acid phosphorylation
5063GO:0007275IEAProcessdevelopment
5063GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5829BAA18998.1paxillin gammaHPRD03937
-9459NP_004831.1Rac/Cdc42 guanine nucleotide exchange factor 6HPRD02226
-28964NP_054749.1G protein-coupled receptor kinase-interactor 1HPRD06577
-9815NP_476510.1G protein-coupled receptor kinase-interactor 2 isoform 1HPRD09779
-9815NP_476510.1G protein-coupled receptor kinase-interactor 2 isoform 1HPRD09779
-8874NP_663788.1Rho guanine nucleotide exchange factor 7 isoform bHPRD05688
NP_002569.1--MEKK1HPRD02142
NP_002569.19459-Rho guanine nucleotide exchange factor 6HPRD02142
NP_002569.18874-Rho guanine nucleotide exchange factor 7HPRD02142
NP_002569.128964-GIT1HPRD02142
NP_002569.15829-PaxillinHPRD02142
NP_002569.11491938NP_057864.1p40BIND300945
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5063IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5063IPR000095PAK_box_Rho_bdPAK-box/P21-Rho-binding
5063IPR000719Prot_kinaseProtein kinase
5063IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5063IPR001245Tyr_pkinaseTyrosine protein kinase
5063IPR013695WAKWall-associated kinase

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