Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5066
Official Symbol:PAM
Other Aliases:PAL|PHM
See related:HGNC:8596|MIM:170270|HPRD:01361
Chromosome:5
Location:5q14-q21
Gene Description:peptidylglycine alpha-amidating monooxygenase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0320
ORGANISM:human
Entrez Gene ID:5066
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18484
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18484CBCerebellum23.023381233215331.9879693984985
18484CTXCerebral cortex100.0100.0
18484HIPHippocampal region84.7316207885742100.0
18484HPFHippocampal formation93.1778602600098100.0
18484HYHypothalamus100.0100.0
18484LSXLateral septal complex100.0100.0
18484MBMidbrain100.0100.0
18484MYMedulla71.5462417602539100.0
18484OLFOlfactory bulb100.0100.0
18484PPons69.341970443725696.9551315307617
18484PALPallidum77.534442901611398.6856117248535
18484RHPRetrohippocampal region100.0100.0
18484sAMYStriatum-like amygdalar nuclei100.0100.0
18484STRStriatum84.04240798950293.447639465332
18484STRdStriatum dorsal region73.186950683593877.8061141967773
18484STRvStriatum ventral region87.673427581787186.6822547912598
18484THThalamus76.337312698364388.4293594360352
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5066GO:0000790IDAComponentnuclear chromatin
5066GO:0000793IDAComponentcondensed chromosome
5066GO:0001519ISSProcesspeptide amidation
5066GO:0003682IDAFunctionchromatin binding
5066GO:0004497IEAFunctionmonooxygenase activity
5066GO:0004504IEAFunctionpeptidylglycine monooxygenase activity
5066GO:0004504NASFunctionpeptidylglycine monooxygenase activity
5066GO:0005507IEAFunctioncopper ion binding
5066GO:0005515IPIFunctionprotein binding
5066GO:0005625NRComponentsoluble fraction
5066GO:0005887NRComponentintegral to plasma membrane
5066GO:0006464TASProcessprotein modification
5066GO:0006518NASProcesspeptide metabolism
5066GO:0007076IMPProcessmitotic chromosome condensation
5066GO:0008270IEAFunctionzinc ion binding
5066GO:0016020IEAComponentmembrane
5066GO:0030141ISSComponentsecretory granule
5066GO:0030141NASComponentsecretory granule
5066GO:0031418IEAFunctionL-ascorbic acid binding
5066GO:0046872IEAFunctionmetal ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8997NP_003938.1kalirin, RhoGEF kinase isoform 2HPRD06859
-9182NP_005438.1peptidylglycine alpha-amidating monooxygenase COOH-terminal interactorHPRD08826
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5066IPR002086Ald_DHAldehyde dehydrogenase
5066IPR000323Cu2_ascorb_mOaseCopper type II, ascorbate-dependent monooxygenase
5066IPR001258NHLNHL repeat
5066IPR000720Pep_amidat_mOasePeptidyl-glycine alpha-amidating monooxygenase
5066AMD_HUMANP19021IPR002086Ald_DHAldehyde dehydrogenase
5066AMD_HUMANP19021IPR000323Cu2_ascorb_mOaseCopper type II, ascorbate-dependent monooxygenase
5066AMD_HUMANP19021IPR001258NHLNHL repeat
5066AMD_HUMANP19021IPR000720Pep_amidat_mOasePeptidyl-glycine alpha-amidating monooxygenase

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