Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5091
Official Symbol:PC
Other Aliases:PCB
See related:HGNC:8636|MIM:608786|HPRD:02032
Chromosome:11
Location:11q13.4-q13.5
Gene Description:pyruvate carboxylase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0071
ORGANISM:human
Entrez Gene ID:5091
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18563
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:QTL0248
ORGANISM:human
Entrez Gene ID:5091
Evidence Type:QTL assay
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18563CBCerebellum23.683187484741266.4977035522461
18563CTXCerebral cortex27.688352584838921.345386505127
18563HIPHippocampal region17.971862792968819.1391181945801
18563HPFHippocampal formation21.458732604980519.863468170166
18563HYHypothalamus10.41609477996839.64710330963135
18563LSXLateral septal complex5.233324050903323.53055810928345
18563MBMidbrain18.314699172973620.1784439086914
18563MYMedulla33.538261413574239.4518432617188
18563OLFOlfactory bulb20.742204666137716.8277683258057
18563PPons25.513437271118228.470193862915
18563PALPallidum15.900808334350616.0653438568115
18563RHPRetrohippocampal region28.559108734130921.6787776947021
18563sAMYStriatum-like amygdalar nuclei6.726169586181645.28631162643433
18563STRStriatum12.40738391876229.08660888671875
18563STRdStriatum dorsal region12.91040134429939.46018981933594
18563STRvStriatum ventral region16.43543243408211.7033224105835
18563THThalamus33.700370788574228.9870662689209
KARG Evidence 3
KARG ID:QTL0248
Trait:METH responses for body temperature
Peak:0
Peak Marker:Gnblps1
Parents:C57BL/6J x DBA/2J intercross
Evidence ID:8987796
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5091GO:0000166IEAFunctionnucleotide binding
5091GO:0004736TASFunctionpyruvate carboxylase activity
5091GO:0005524TASFunctionATP binding
5091GO:0005739IEAComponentmitochondrion
5091GO:0006094IEAProcessgluconeogenesis
5091GO:0008152IEAProcessmetabolism
5091GO:0008610IEAProcesslipid biosynthesis
5091GO:0009374TASFunctionbiotin binding
5091GO:0016874IEAFunctionligase activity
5091GO:0030145IEAFunctionmanganese ion binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5091PYC_HUMANP11498IPR003135ATP-graspATP-dependent carboxylate-amine ligase-like, ATP-grasp
5091PYC_HUMANP11498IPR001882Biotin_BSBiotin-binding site
5091PYC_HUMANP11498IPR005482Biotin_carb_CBiotin carboxylase, C-terminal
5091PYC_HUMANP11498IPR000089Biotin_lipoylBiotin/lipoyl attachment
5091PYC_HUMANP11498IPR005483CPase_LCarbamoyl-phosphate synthetase large chain
5091PYC_HUMANP11498IPR005481CPase_L_NCarbamoyl-phosphate synthetase large chain, N-terminal
5091PYC_HUMANP11498IPR005479CPSase_D2_ATP_bdCarbamoyl-phosphate synthase L chain, ATP-binding
5091PYC_HUMANP11498IPR003379PYC_OADAConserved carboxylase region
5091PYC_HUMANP11498IPR000891PYR_CTPyruvate carboxyltransferase

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