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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry

For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information Gene ID: 51 Official Symbol: ACOX1 Other Aliases: ACOX|MGC1198|PALMCOX|SCOX See related: HGNC:119|MIM:609751|HPRD:02030 Chromosome: 17 Location: 17q24-q25|17q25.1 Gene Description: acyl-Coenzyme A oxidase 1, palmitoyl Gene type: protein-coding Gene Structure: Genomic Context: KARG Evidence 1 KARG ID: EVIM0316 ORGANISM: human Entrez Gene ID: 51 Evidence Type: Microarray Evidence ID Type: PUBMED Evidence ID: 15816859 Addiction Drug: ALCOHOL Addiction Drug Detail: ALCOHOL ABUSE Addiction Brain Area: Nucleus Accumbens Drug Effects: Upregulated Fold Change: 0.94 Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas) Mouse Entrez Gene ID Brain Region Brain Region Detail Expression Level Expression Density 11430 CB Cerebellum 67.7250595092773 100.0 11430 CTX Cerebral cortex 100.0 100.0 11430 HIP Hippocampal region 100.0 100.0 11430 HPF Hippocampal formation 100.0 100.0 11430 HY Hypothalamus 100.0 100.0 11430 LSX Lateral septal complex 100.0 100.0 11430 MB Midbrain 86.4716567993164 95.8877487182617 11430 MY Medulla 57.7739372253418 71.3618545532227 11430 OLF Olfactory bulb 97.1799240112305 100.0 11430 P Pons 65.6843643188477 78.981819152832 11430 PAL Pallidum 86.7606658935547 96.7022018432617 11430 RHP Retrohippocampal region 100.0 100.0 11430 sAMY Striatum-like amygdalar nuclei 100.0 100.0 11430 STR Striatum 100.0 95.0094451904297 11430 STRd Striatum dorsal region 96.6344680786133 89.6015701293945 11430 STRv Striatum ventral region 100.0 96.1481094360352 11430 TH Thalamus 96.4203948974609 100.0 Gene Ontology Gene ID GO ID Evidence GO Type GO Description 51 GO:0003995 IEA Function acyl-CoA dehydrogenase activity 51 GO:0003997 NAS Function acyl-CoA oxidase activity 51 GO:0005777 NAS Component peroxisome 51 GO:0006118 IEA Process electron transport 51 GO:0006629 TAS Process lipid metabolism 51 GO:0006635 IEA Process fatty acid beta-oxidation 51 GO:0006693 NAS Process prostaglandin metabolism 51 GO:0009053 NR Function electron donor activity 51 GO:0016491 IEA Function oxidoreductase activity 51 GO:0050660 IEA Function FAD binding Interaction Information Gene Product ID Interactant Gene ID Interactant Gene Product ID Interactant Gene Product Name Source Source ID NP_004026.2 6342 - Sterol carrier protein 2 HPRD 02030 Domain Information Gene ID Uniprot/Swissprot ID Uniprot/Swissprot ACC Interpro ID Interpro Short Description Interpro Long Description 51 IPR006091 Acyl_CoA_DH_M Acyl-CoA dehydrogenase, central region 51 IPR002655 Acyl_CoA_ox_C Acyl-CoA oxidase, C-terminal 51 IPR000634 S_T_dehydrtse_BS Serine/threonine dehydratase, pyridoxal-phosphate-binding site 51 IPR001412 tRNA-synt_I Aminoacyl-tRNA synthetase, class I 51 ACOX1_HUMAN Q15067 IPR006091 Acyl_CoA_DH_M Acyl-CoA dehydrogenase, central region 51 ACOX1_HUMAN Q15067 IPR002655 Acyl_CoA_ox_C Acyl-CoA oxidase, C-terminal 51 ACOX1_HUMAN Q15067 IPR000634 S_T_dehydrtse_BS Serine/threonine dehydratase, pyridoxal-phosphate-binding site 51 ACOX1_HUMAN Q15067 IPR001412 tRNA-synt_I Aminoacyl-tRNA synthetase, class I © Center for Bioinformatics(CBI), Peking University Any Comments and suggestions to : KARG GROUP.