Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:51
Official Symbol:ACOX1
Other Aliases:ACOX|MGC1198|PALMCOX|SCOX
See related:HGNC:119|MIM:609751|HPRD:02030
Chromosome:17
Location:17q24-q25|17q25.1
Gene Description:acyl-Coenzyme A oxidase 1, palmitoyl
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0316
ORGANISM:human
Entrez Gene ID:51
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.94
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11430CBCerebellum67.7250595092773100.0
11430CTXCerebral cortex100.0100.0
11430HIPHippocampal region100.0100.0
11430HPFHippocampal formation100.0100.0
11430HYHypothalamus100.0100.0
11430LSXLateral septal complex100.0100.0
11430MBMidbrain86.471656799316495.8877487182617
11430MYMedulla57.773937225341871.3618545532227
11430OLFOlfactory bulb97.1799240112305100.0
11430PPons65.684364318847778.981819152832
11430PALPallidum86.760665893554796.7022018432617
11430RHPRetrohippocampal region100.0100.0
11430sAMYStriatum-like amygdalar nuclei100.0100.0
11430STRStriatum100.095.0094451904297
11430STRdStriatum dorsal region96.634468078613389.6015701293945
11430STRvStriatum ventral region100.096.1481094360352
11430THThalamus96.4203948974609100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
51GO:0003995IEAFunctionacyl-CoA dehydrogenase activity
51GO:0003997NASFunctionacyl-CoA oxidase activity
51GO:0005777NASComponentperoxisome
51GO:0006118IEAProcesselectron transport
51GO:0006629TASProcesslipid metabolism
51GO:0006635IEAProcessfatty acid beta-oxidation
51GO:0006693NASProcessprostaglandin metabolism
51GO:0009053NRFunctionelectron donor activity
51GO:0016491IEAFunctionoxidoreductase activity
51GO:0050660IEAFunctionFAD binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_004026.26342-Sterol carrier protein 2HPRD02030
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
51IPR006091Acyl_CoA_DH_MAcyl-CoA dehydrogenase, central region
51IPR002655Acyl_CoA_ox_CAcyl-CoA oxidase, C-terminal
51IPR000634S_T_dehydrtse_BSSerine/threonine dehydratase, pyridoxal-phosphate-binding site
51IPR001412tRNA-synt_IAminoacyl-tRNA synthetase, class I
51ACOX1_HUMANQ15067IPR006091Acyl_CoA_DH_MAcyl-CoA dehydrogenase, central region
51ACOX1_HUMANQ15067IPR002655Acyl_CoA_ox_CAcyl-CoA oxidase, C-terminal
51ACOX1_HUMANQ15067IPR000634S_T_dehydrtse_BSSerine/threonine dehydratase, pyridoxal-phosphate-binding site
51ACOX1_HUMANQ15067IPR001412tRNA-synt_IAminoacyl-tRNA synthetase, class I

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