Knowledgebase for Addiction-Related Genes
Home | Score | Chromosome | Pathway | Advanced Search | BLAST Search | Downloads | Publications | FAQ & Help |   

KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5105
Official Symbol:PCK1
Other Aliases:MGC22652|PEPCK1|PEPCKC
See related:HGNC:8724|MIM:261680|HPRD:02028
Chromosome:20
Location:20q13.31
Gene Description:phosphoenolpyruvate carboxykinase 1 (soluble)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0317
ORGANISM:human
Entrez Gene ID:5105
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:0.68
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18534CBCerebellum0.5345185995101931.14070773124695
18534CTXCerebral cortex1.624992251396181.76656067371368
18534HIPHippocampal region1.328814864158631.21948456764221
18534HPFHippocampal formation0.8695439696311950.779729187488556
18534HYHypothalamus0.05876381322741510.0469272471964359
18534LSXLateral septal complex0.3911836445331570.453483700752258
18534MBMidbrain0.5584844350814821.01578724384308
18534MYMedulla0.2210989892482760.671578168869019
18534OLFOlfactory bulb0.5542400479316711.74052512645721
18534PPons0.5193226337432861.65807235240936
18534PALPallidum0.2002642303705220.199077889323235
18534RHPRetrohippocampal region0.1316100507974620.205370679497719
18534sAMYStriatum-like amygdalar nuclei0.252773910760880.698252439498901
18534STRStriatum0.2173338830471040.287298291921616
18534STRdStriatum dorsal region0.1957148611545560.235337898135185
18534STRvStriatum ventral region0.2571036815643310.255646198987961
18534THThalamus0.671523272991180.722271263599396
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5105GO:0000166IEAFunctionnucleotide binding
5105GO:0004613TASFunctionphosphoenolpyruvate carboxykinase (GTP) activity
5105GO:0005525IEAFunctionGTP binding
5105GO:0005829NRComponentcytosol
5105GO:0006094IEAProcessgluconeogenesis
5105GO:0016829IEAFunctionlyase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002582.2155348NP_705928.1integraseBIND145593
NP_002582.2155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5105PPCKC_HUMANP35558IPR008209PEP_carboxykinPhosphoenolpyruvate carboxykinase (GTP)

© Center for Bioinformatics(CBI), Peking University
Any Comments and suggestions to : KARG GROUP.