Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:51196
Official Symbol:PLCE1
Other Aliases:FLJ23659|KIAA1516|PLCE
See related:HGNC:17175|MIM:608414|HPRD:07087
Chromosome:10
Location:10q23
Gene Description:phospholipase C, epsilon 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:HOT0125
ORGANISM:human
Entrez Gene ID:51196
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
74055CBCerebellum3.29784011840823.9565589427948
74055CTXCerebral cortex1.125431180000312.19197821617126
74055HIPHippocampal region0.5286707282066350.510058999061584
74055HPFHippocampal formation0.4418107867240910.406300038099289
74055HYHypothalamus0.6055266261100770.69533497095108
74055LSXLateral septal complex0.8006915450096130.914251208305359
74055MBMidbrain1.253202199935911.74080491065979
74055MYMedulla3.213417053222664.56137561798096
74055OLFOlfactory bulb3.238089799880983.63994383811951
74055PPons1.573460459709172.21913051605225
74055PALPallidum0.3515852093696590.318914979696274
74055RHPRetrohippocampal region0.2849130332469940.230215579271317
74055sAMYStriatum-like amygdalar nuclei0.3859966099262240.310013741254807
74055STRStriatum0.4158622324466710.485760003328323
74055STRdStriatum dorsal region0.367765277624130.547398686408997
74055STRvStriatum ventral region0.3223553895950320.199225142598152
74055THThalamus0.5990305542945860.925229012966156
KARG Evidence 2
KARG ID:HOT0125
Entrez Gene ID:51196
RefSeq ID:NM_016341
Position Information:+, Intron, 0bp
Linkage Marker:D10S677
Evidence Type:LINKAGE-BASED (MULTI POINTS)
Evidence Name:PUBMED
Evidence ID:10208445
Addiction Drug:TOBACCO
Addiction Drug Detail:HABITUAL SMOKING ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
51196GO:0004435IEAFunctionphosphoinositide phospholipase C activity
51196GO:0005085IEAFunctionguanyl-nucleotide exchange factor activity
51196GO:0005509IEAFunctioncalcium ion binding
51196GO:0005622IEAComponentintracellular
51196GO:0006629IEAProcesslipid metabolism
51196GO:0007264IEAProcesssmall GTPase mediated signal transduction
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_057425.2--RasHPRD07087
NP_057425.2155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
51196IPR000008C2C2
51196IPR001192PI_PLCPhosphoinositide-specific phospholipase C (PLC)
51196IPR000909PI_PLC_XPhosphatidylinositol-specific phospholipase C, X region
51196IPR001711PI_PLC_YPhosphatidylinositol-specific phospholipase C, Y domain
51196IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
51196IPR000159RARA
51196IPR001895RasGRF_CDC25Guanine-nucleotide dissociation stimulator CDC25

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