Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5126
Official Symbol:PCSK2
Other Aliases:NEC2|PC2|SPC2
See related:HGNC:8744|MIM:162151|HPRD:01202
Chromosome:20
Location:20p11.2
Gene Description:proprotein convertase subtilisin/kexin type 2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0154
ORGANISM:human
Entrez Gene ID:5126
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:1.92 :: 1.90 :: 1.53 :: 1.34 :: -1.57 :: -1.51 :: -0.33
KARG Evidence 2
KARG ID:HOT0170
ORGANISM:human
Entrez Gene ID:5126
Evidence Type:Whole Genome Association
Evidence ID Type:PUBMED
Evidence ID:NA
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18549CBCerebellum51.376253128051874.3638114929199
18549CTXCerebral cortex100.0100.0
18549HIPHippocampal region100.0100.0
18549HPFHippocampal formation100.0100.0
18549HYHypothalamus92.643238067627100.0
18549LSXLateral septal complex92.470390319824295.8323631286621
18549MBMidbrain100.0100.0
18549MYMedulla79.3707084655762100.0
18549OLFOlfactory bulb100.0100.0
18549PPons73.23467636108497.6789207458496
18549PALPallidum54.529922485351668.2255916595459
18549RHPRetrohippocampal region100.0100.0
18549sAMYStriatum-like amygdalar nuclei98.3735542297363100.0
18549STRStriatum100.0100.0
18549STRdStriatum dorsal region100.0100.0
18549STRvStriatum ventral region100.0100.0
18549THThalamus100.0100.0
KARG Evidence 3
KARG ID:HOT0170
Entrez Gene ID:5126
RefSeq ID:NM_002594
Position Information:+, Intron, 0bp
Linkage Marker:D20S112
Evidence Type:LINKAGE-BASED (SINGLE POINT)
Evidence Name:PUBMED
Evidence ID:12757967
Addiction Drug:POLYSUBSTANCE
Addiction Drug Detail:POLYSUBSTANCE ABUSE
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5126GO:0004286IEAFunctionproprotein convertase 2 activity
5126GO:0004289IEAFunctionsubtilase activity
5126GO:0004289TASFunctionsubtilase activity
5126GO:0005515IPIFunctionprotein binding
5126GO:0005615TASComponentextracellular space
5126GO:0005794TASComponentGolgi apparatus
5126GO:0006508IEAProcessproteolysis
5126GO:0006508TASProcessproteolysis
5126GO:0007267TASProcesscell-cell signaling
5126GO:0008233IEAFunctionpeptidase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002585.26447-Secretory granule neuroendocrine protein 1HPRD01202
S75955.17067NP_955366.1thyroid hormone receptor, alpha isoform 1BIND215927
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5126NEC2_HUMANP16519IPR000209Pept_S8_S53Peptidase S8 and S53, subtilisin, kexin, sedolisin
5126NEC2_HUMANP16519IPR002884PrprotnconvertsPProprotein convertase, P

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