Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:51400
Official Symbol:PPME1
Other Aliases:FLJ22226|PME-1
See related:HGNC:30178|HPRD:17864
Chromosome:11
Location:11q13.4
Gene Description:protein phosphatase methylesterase 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0149
ORGANISM:human
Entrez Gene ID:51400
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.60 :: 2.81 :: 0.45 :: -2.43 :: -2.37 :: -3.09 :: -2.30
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
72590CBCerebellum48.200653076171975.79443359375
72590CTXCerebral cortex100.0100.0
72590HIPHippocampal region100.0100.0
72590HPFHippocampal formation100.0100.0
72590HYHypothalamus90.899551391601688.8372955322266
72590LSXLateral septal complex74.963523864746170.9214019775391
72590MBMidbrain77.643615722656284.8213882446289
72590MYMedulla64.924705505371177.6331481933594
72590OLFOlfactory bulb99.8820114135742100.0
72590PPons73.552444458007890.7659759521484
72590PALPallidum88.007316589355598.0217208862305
72590RHPRetrohippocampal region100.0100.0
72590sAMYStriatum-like amygdalar nuclei100.0100.0
72590STRStriatum97.161712646484484.5231475830078
72590STRdStriatum dorsal region98.219207763671984.8486480712891
72590STRvStriatum ventral region96.392761230468879.1802597045898
72590THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
51400GO:0004759IEAFunctionserine esterase activity
51400GO:0004864TASFunctionprotein phosphatase inhibitor activity
51400GO:0005515IDAFunctionprotein binding
51400GO:0006482IDAProcessprotein amino acid demethylation
51400GO:0006725IEAProcessaromatic compound metabolism
51400GO:0008601TASFunctionprotein phosphatase type 2A regulator activity
51400GO:0016787IEAFunctionhydrolase activity
51400GO:0016789IDAFunctioncarboxylic ester hydrolase activity
51400GO:0051721IDAFunctionprotein phosphatase 2A binding
51400GO:0051722IDAFunctionprotein C-terminal methylesterase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
51400PPME1_HUMANQ9Y570IPR000073AB_hydrolase_1Alpha/beta hydrolase fold-1
51400PPME1_HUMANQ9Y570IPR003089AB_hydrolaseAlpha/beta hydrolase
51400PPME1_HUMANQ9Y570IPR000639Epox_hydrolaseEpoxide hydrolase
51400PPME1_HUMANQ9Y570IPR008262Lipase_ASLipase, active site
51400PPME1_HUMANQ9Y570IPR002410Peptidase_S33Peptidase S33, prolyl aminopeptidase
51400PPME1_HUMANQ9Y570IPR000379Ser_estrsEsterase/lipase/thioesterase

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