Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5153
Official Symbol:PDE1B
Other Aliases:PDE1B1|PDES1B
See related:HGNC:8775|MIM:171891|HPRD:01388
Chromosome:12
Location:12q13
Gene Description:phosphodiesterase 1B, calmodulin-dependent
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0301
ORGANISM:human
Entrez Gene ID:5153
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18574
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18574CBCerebellum4.064977169036874.35400161147118
18574CTXCerebral cortex16.842112302780212.1895990371704
18574HIPHippocampal region29.422587871551533.5229563713074
18574HPFHippocampal formation30.547237396240229.6001515388489
18574HYHypothalamus13.12410032749188.76218712329865
18574LSXLateral septal complex16.178313195705411.8003259897232
18574MBMidbrain17.539751887321513.2428612709045
18574MYMedulla18.951039075851417.7248973846436
18574OLFOlfactory bulb49.960651397705130.1352291107178
18574PPons18.540006875991818.0675196647644
18574PALPallidum27.258367538452133.0579051971436
18574RHPRetrohippocampal region32.17831897735622.9203968048096
18574sAMYStriatum-like amygdalar nuclei35.506138801574729.4544887542725
18574STRStriatum100.0100.0
18574STRdStriatum dorsal region100.0100.0
18574STRvStriatum ventral region100.0100.0
18574THThalamus18.548383831977813.7129426598549
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5153GO:0004117TASFunctioncalmodulin-dependent cyclic-nucleotide phosphodiesterase activity
5153GO:0005516IEAFunctioncalmodulin binding
5153GO:0006915TASProcessapoptosis
5153GO:0007165IEAProcesssignal transduction
5153GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_000915.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5153PDE1B_HUMANQ01064IPR002073PDEase3'5'-cyclic nucleotide phosphodiesterase
5153PDE1B_HUMANQ01064IPR013706PDEase_N3,5,-cyclic nucleotide phosphodiesterase N-terminal

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