Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5162
Official Symbol:PDHB
Other Aliases:DKFZp564K0164|PHE1B
See related:HGNC:8808|MIM:179060|HPRD:01530
Chromosome:3
Location:3p21.1-p14.2
Gene Description:pyruvate dehydrogenase (lipoamide) beta
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIP0219
ORGANISM:human
Entrez Gene ID:5162
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.46
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
68263CBCerebellum60.909725189209100.0
68263CTXCerebral cortex100.0100.0
68263HIPHippocampal region100.0100.0
68263HPFHippocampal formation100.0100.0
68263HYHypothalamus100.0100.0
68263LSXLateral septal complex100.0100.0
68263MBMidbrain100.0100.0
68263MYMedulla100.0100.0
68263OLFOlfactory bulb100.0100.0
68263PPons100.0100.0
68263PALPallidum100.0100.0
68263RHPRetrohippocampal region100.0100.0
68263sAMYStriatum-like amygdalar nuclei100.0100.0
68263STRStriatum100.0100.0
68263STRdStriatum dorsal region100.0100.0
68263STRvStriatum ventral region100.0100.0
68263THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5162GO:0004739TASFunctionpyruvate dehydrogenase (acetyl-transferring) activity
5162GO:0005739IEAComponentmitochondrion
5162GO:0006006NRProcessglucose metabolism
5162GO:0006096IEAProcessglycolysis
5162GO:0006099TASProcesstricarboxylic acid cycle
5162GO:0016491IEAFunctionoxidoreductase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8050NP_003468.1pyruvate dehydrogenase complex, component XHPRD02002
NP_000916.1--Pyruvate dehydrogenase, alpha polypeptideHPRD01530
NP_000916.18050-Pyruvate dehydrogenase complex, component XHPRD01530
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5162ODPB_HUMANP11177IPR005475Transketo_Cen_RTransketolase, central region
5162ODPB_HUMANP11177IPR005476Transketo_CTransketolase, C-terminal
5162ODPB_HUMANP11177IPR012058Transketo_N_RTransketolase N-terminal region

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