Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5166
Official Symbol:PDK4
Other Aliases:FLJ40832
See related:HGNC:8812|MIM:602527|HPRD:03957
Chromosome:7
Location:7q21.3
Gene Description:pyruvate dehydrogenase kinase, isozyme 4
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0243
ORGANISM:human
Entrez Gene ID:5166
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:27273
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
27273CBCerebellum1.195389509201052.28133845329285
27273CTXCerebral cortex0.3383307158946990.39845135807991
27273HIPHippocampal region0.7284793853759770.893846094608307
27273HPFHippocampal formation0.6806712150573730.81437212228775
27273HYHypothalamus0.8523370623588561.18301236629486
27273LSXLateral septal complex0.5450072884559630.545237720012665
27273MBMidbrain0.6455576419830321.07514572143555
27273MYMedulla5.742620944976816.93673133850098
27273OLFOlfactory bulb2.107842206954963.17697644233704
27273PPons2.194445610046392.90960550308228
27273PALPallidum0.2938258945941930.242468655109406
27273RHPRetrohippocampal region0.3405227363109590.34802782535553
27273sAMYStriatum-like amygdalar nuclei1.072691917419430.908679783344269
27273STRStriatum0.7401148080825810.642931640148163
27273STRdStriatum dorsal region0.6666018366813660.610161662101746
27273STRvStriatum ventral region0.9771400094032290.732068419456482
27273THThalamus0.3177736699581150.305845350027084
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5166GO:0004740TASFunction[pyruvate dehydrogenase (lipoamide)] kinase activity
5166GO:0005524IEAFunctionATP binding
5166GO:0005739TASComponentmitochondrion
5166GO:0006006TASProcessglucose metabolism
5166GO:0006468IEAProcessprotein amino acid phosphorylation
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5166PDK4_HUMANQ16654IPR003594ATP_bd_ATPaseATP-binding region, ATPase-like
5166PDK4_HUMANQ16654IPR005467His_kinaseHistidine kinase
5166PDK4_HUMANQ16654IPR004358His_kin_like_CHistidine kinase related protein, C-terminal

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