Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5168
Official Symbol:ENPP2
Other Aliases:ATX|ATX-X|FLJ26803|LysoPLD|NPP2|PD-IALPHA|PDNP2
See related:HGNC:3357|MIM:601060|HPRD:03037
Chromosome:8
Location:8q24.1
Gene Description:ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0406
ORGANISM:human
Entrez Gene ID:5168
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:84050
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0173
ORGANISM:human
Entrez Gene ID:5168
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15312160
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 3
KARG ID:EVIM0391
ORGANISM:human
Entrez Gene ID:5168
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.4 :: -1 :: 1.7 :: 1.8 :: 1.8 :: 1.4
KARG Evidence 4
KARG ID:EVIM0459
ORGANISM:human
Entrez Gene ID:5168
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.4 :: 1.3 :: -1.1 :: 2.4 :: 1
KARG Evidence 5
KARG ID:EVIM0946
ORGANISM:human
Entrez Gene ID:5168
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-1.6 :: -1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18606CBCerebellum85.6256828308105100.0
18606CTXCerebral cortex100.0100.0
18606HIPHippocampal region59.089567184448280.9195442199707
18606HPFHippocampal formation68.81918525695887.0854949951172
18606HYHypothalamus95.108562469482496.5340232849121
18606LSXLateral septal complex100.0100.0
18606MBMidbrain100.0100.0
18606MYMedulla100.0100.0
18606OLFOlfactory bulb86.259212493896596.0597305297852
18606PPons100.0100.0
18606PALPallidum100.0100.0
18606RHPRetrohippocampal region82.803318023681690.3889389038086
18606sAMYStriatum-like amygdalar nuclei88.288139343261787.27734375
18606STRStriatum90.878147125244192.2217254638672
18606STRdStriatum dorsal region96.009449005127100.0
18606STRvStriatum ventral region65.874244689941459.070463180542
18606THThalamus94.590805053710996.2965240478516
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5168GO:0003676IEAFunctionnucleic acid binding
5168GO:0004519IEAFunctionendonuclease activity
5168GO:0004528TASFunctionphosphodiesterase I activity
5168GO:0004551TASFunctionnucleotide diphosphatase activity
5168GO:0005886TASComponentplasma membrane
5168GO:0005887TASComponentintegral to plasma membrane
5168GO:0006796TASProcessphosphate metabolism
5168GO:0006928TASProcesscell motility
5168GO:0006935NASProcesschemotaxis
5168GO:0007186TASProcessG-protein coupled receptor protein signaling pathway
5168GO:0008134TASFunctiontranscription factor binding
5168GO:0009117IEAProcessnucleotide metabolism
5168GO:0016787TASFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5168IPR001604EndonucleaseDNA/RNA non-specific endonuclease
5168IPR001472NLS_BPBipartite nuclear localization signal
5168IPR002591PhosphodiestType I phosphodiesterase/nucleotide pyrophosphatase
5168IPR001212Somatomedin_BSomatomedin B

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