Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5170
Official Symbol:PDPK1
Other Aliases:MGC20087|MGC35290|PDK1|PRO0461|PkB-like|PkB-like 1
See related:HGNC:8816|MIM:605213|HPRD:05556
Chromosome:16
Location:16p13.3
Gene Description:3-phosphoinositide dependent protein kinase-1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0155
ORGANISM:human
Entrez Gene ID:5170
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18607
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18607CBCerebellum17.63824081420920.6405162811279
18607CTXCerebral cortex86.600990295410276.0252914428711
18607HIPHippocampal region59.6009254455566100.0
18607HPFHippocampal formation50.659297943115272.2184906005859
18607HYHypothalamus15.559919357299813.7765779495239
18607LSXLateral septal complex22.785804748535219.3837032318115
18607MBMidbrain24.660871505737325.1696147918701
18607MYMedulla28.188642501831135.3251457214355
18607OLFOlfactory bulb47.605300903320343.1212196350098
18607PPons25.706157684326232.6362342834473
18607PALPallidum23.196701049804724.1298999786377
18607RHPRetrohippocampal region36.477138519287133.5785713195801
18607sAMYStriatum-like amygdalar nuclei38.100452423095732.3630752563477
18607STRStriatum83.4155273437570.4415588378906
18607STRdStriatum dorsal region100.087.7568511962891
18607STRvStriatum ventral region76.355209350585962.0536041259766
18607THThalamus20.471712112426818.9723701477051
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5170GO:0000166IEAFunctionnucleotide binding
5170GO:0004672IEAFunctionprotein kinase activity
5170GO:0004676TASFunction3-phosphoinositide-dependent protein kinase activity
5170GO:0005524IEAFunctionATP binding
5170GO:0005737IEPComponentcytoplasm
5170GO:0005886IEPComponentplasma membrane
5170GO:0006468IEAProcessprotein amino acid phosphorylation
5170GO:0006468TASProcessprotein amino acid phosphorylation
5170GO:0008286TASProcessinsulin receptor signaling pathway
5170GO:0016740IEAFunctiontransferase activity
5170GO:0030036TASProcessactin cytoskeleton organization and biogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-5585NP_002732.1protein kinase C-like 1HPRD03019
-5590NP_002735.3protein kinase C, zeta isoform 1BIND262387
-6198NP_003152.1ribosomal protein S6 kinase, 70kDa, polypeptide 1HPRD10202
-6197NP_004577.1ribosomal protein S6 kinase, 90kDa, polypeptide 3HPRD02092
-9351NP_004776.1solute carrier family 9 isoform 3 regulator 2HPRD05946
-5581NP_005391.1protein kinase C, epsilonBIND262391
-6446NP_005618.2serum/glucocorticoid regulated kinaseHPRD04264
-5583NP_006246.2protein kinase C, etaBIND262389
-5586NP_006247.1protein kinase N2HPRD03972
-5900NP_006257.1ral guanine nucleotide dissociation stimulatorHPRD03371
-64400NP_071921.1fused toes homologHPRD07467
NP_002604.1--PKAHPRD05556
NP_002604.16446-Serum/glucocorticoid regulated kinaseHPRD05556
NP_002604.15586-Protein kinase C like 2HPRD05556
NP_002604.15585-PKNHPRD05556
NP_002604.16197-Ribosomal protein S6 kinase alpha 3HPRD05556
NP_002604.15579-Protein kinase C, beta 1HPRD05556
NP_002604.15580-Protein kinase C deltaHPRD05556
NP_002604.15900-Ral guanine nucleotide dissociation stimulatorHPRD05556
NP_002604.19351-Solute carrier family 9, isoform 3, regulatory factor 2HPRD05556
NP_002604.164400-FTSHPRD05556
NP_002604.15580BAA01381.1protein kinase C delta-typeBIND217406
NP_002604.15584NP_002731.3protein kinase C, iotaHPRD05556
NP_002604.15584NP_002731.3protein kinase C, iotaHPRD02105
NP_002604.15590NP_002735.2protein kinase C, zetaHPRD05556
NP_002604.15590NP_002735.3protein kinase C, zeta isoform 1BIND217407
NP_002604.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD05556
NP_002604.17533NP_003396.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptideHPRD00215
NP_002604.15586NP_006247.1protein kinase N2BIND217408
NP_002604.15588NP_006248.1protein kinase C, thetaBIND209039
NP_002604.110971NP_006817.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptideHPRD00886
NP_002604.110971NP_006817.1tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptideHPRD05556
NP_002604.184433NP_115791.2caspase recruitment domain family, member 11BIND209044
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5170IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5170IPR000719Prot_kinaseProtein kinase
5170IPR013695WAKWall-associated kinase
5170PDPK1_HUMANO15530IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5170PDPK1_HUMANO15530IPR000719Prot_kinaseProtein kinase
5170PDPK1_HUMANO15530IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5170PDPK1_HUMANO15530IPR001245Tyr_pkinaseTyrosine protein kinase
5170PDPK1_HUMANO15530IPR013695WAKWall-associated kinase

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