Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5173
Official Symbol:PDYN
Other Aliases:MGC26418|PENKB
See related:HGNC:8820|MIM:131340|HPRD:08838
Chromosome:20
Location:20pter-p12
Gene Description:prodynorphin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0229
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18610
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0436
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29190
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0032
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:9862779
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ADMINISTRATION
Addiction Brain Area:Nucleus Accumbens
Drug Effects:
Fold Change:
KARG Evidence 4
KARG ID:EVIL0066
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:11992566
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 5
KARG ID:EVIL0203
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16184603
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 6
KARG ID:EVIL0208
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:16314761
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIOID ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 7
KARG ID:EVIM0068
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Upregulated
Fold Change:-0.31 :: 0.02 :: 0.35 :: 0.29 :: 1.12 :: 0.37 :: 0.56 :: 0.53 :: -0.06 :: 0.22
KARG Evidence 8
KARG ID:EVIP0222
ORGANISM:human
Entrez Gene ID:5173
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:15542695
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Whole Brain
Drug Effects:Downregulated
Fold Change:0.44
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18610CBCerebellum12.871445178985616.7270693778992
18610CTXCerebral cortex27.564991950988832.2092113494873
18610HIPHippocampal region23.011371612548843.168327331543
18610HPFHippocampal formation17.517180442810127.9697704315186
18610HYHypothalamus26.860074996948237.5281963348389
18610LSXLateral septal complex22.06728935241735.0052423477173
18610MBMidbrain13.518477439880415.8425469398499
18610MYMedulla16.311916828155521.0819339752197
18610OLFOlfactory bulb24.819181442260724.084023475647
18610PPons14.116418361663817.6613974571228
18610PALPallidum28.251079559326244.368803024292
18610RHPRetrohippocampal region8.929435014724739.24852776527405
18610sAMYStriatum-like amygdalar nuclei46.811012268066467.8442687988281
18610STRStriatum89.9340553283691100.0
18610STRdStriatum dorsal region87.490234375100.0
18610STRvStriatum ventral region100.0100.0
18610THThalamus24.462660789489725.5865640640259
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5173GO:0001515IEAFunctionopioid peptide activity
5173GO:0005886IDAComponentplasma membrane
5173GO:0007218IEAProcessneuropeptide signaling pathway
5173GO:0007268IEAProcesssynaptic transmission
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5173PDYN_HUMANP01213IPR006024Opioid_neupeptOpioid neuropeptide precursor
5173PDYN_HUMANP01213IPR000750Proenkphlin_BProenkephalin B

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