Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5176
Official Symbol:SERPINF1
Other Aliases:EPC-1|PEDF|PIG35
See related:HGNC:8824|MIM:172860|HPRD:01408
Chromosome:17
Location:17p13.1
Gene Description:serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0975
ORGANISM:human
Entrez Gene ID:5176
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.1 :: 1.2 :: 1.6 :: 1.4
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
20317CBCerebellum10.304728507995611.6431674957275
20317CTXCerebral cortex3.873018980026252.22105383872986
20317HIPHippocampal region7.368756294250496.09259939193726
20317HPFHippocampal formation7.388486385345465.22670221328735
20317HYHypothalamus4.08635616302493.18861174583435
20317LSXLateral septal complex5.721821784973143.28824543952942
20317MBMidbrain6.676428318023686.01741313934326
20317MYMedulla13.001791954040512.9260768890381
20317OLFOlfactory bulb7.227821826934813.93957853317261
20317PPons9.864014625549329.25538444519043
20317PALPallidum5.810341835021974.67481231689453
20317RHPRetrohippocampal region7.142617225646973.97691679000854
20317sAMYStriatum-like amygdalar nuclei3.547322273254393.08102917671204
20317STRStriatum3.287081241607672.48270511627197
20317STRdStriatum dorsal region2.954519748687742.28569149971008
20317STRvStriatum ventral region3.236562728881842.44656014442444
20317THThalamus8.673605918884286.99403810501099
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5176GO:0004867TASFunctionserine-type endopeptidase inhibitor activity
5176GO:0005576IDAComponentextracellular region
5176GO:0007275TASProcessdevelopment
5176GO:0008283TASProcesscell proliferation
5176GO:0016525IDAProcessnegative regulation of angiogenesis
5176GO:0050769IDAProcesspositive regulation of neurogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5176PEDF_HUMANP36955IPR000295Prot_inh_Lserp2Proteinase inhibitor I4, leuserpin 2
5176PEDF_HUMANP36955IPR000215Prot_inh_serpinProteinase inhibitor I4, serpin

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