Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5179
Official Symbol:PENK
Other Aliases:-
See related:HGNC:8831|MIM:131330|HPRD:08837
Chromosome:8
Location:8q23-q24
Gene Description:proenkephalin
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0117
ORGANISM:human
Entrez Gene ID:5179
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18619
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0538
ORGANISM:human
Entrez Gene ID:5179
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29237
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 3
KARG ID:EVIL0035
ORGANISM:human
Entrez Gene ID:5179
Evidence Type:LT Reports
Evidence ID Type:PUBMED
Evidence ID:10321497
Addiction Drug:OPIOIDS
Addiction Drug Detail:OPIOID ABUSE
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18619CBCerebellum68.7525978088379100.0
18619CTXCerebral cortex40.219394683837962.7337055206299
18619HIPHippocampal region27.084275245666558.4452571868896
18619HPFHippocampal formation26.201870918273953.1500244140625
18619HYHypothalamus45.353134155273483.6812591552734
18619LSXLateral septal complex43.12203407287684.8839149475098
18619MBMidbrain48.277410507202181.2595977783203
18619MYMedulla49.725111007690499.6492729187012
18619OLFOlfactory bulb90.5763893127441100.0
18619PPons42.029506683349677.6518211364746
18619PALPallidum54.3779201507568100.0
18619RHPRetrohippocampal region25.319495201110846.8279132843018
18619sAMYStriatum-like amygdalar nuclei82.8066864013672100.0
18619STRStriatum100.0100.0
18619STRdStriatum dorsal region100.0100.0
18619STRvStriatum ventral region100.0100.0
18619THThalamus8.897551059722915.3815002441406
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5179GO:0001515IEAFunctionopioid peptide activity
5179GO:0005184TASFunctionneuropeptide hormone activity
5179GO:0005625NRComponentsoluble fraction
5179GO:0007165TASProcesssignal transduction
5179GO:0007218IEAProcessneuropeptide signaling pathway
5179GO:0007267NRProcesscell-cell signaling
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5179PENK_HUMANP01210IPR006024Opioid_neupeptOpioid neuropeptide precursor
5179PENK_HUMANP01210IPR000703Proenkphlin_AProenkephalin A

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