Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5216
Official Symbol:PFN1
Other Aliases:-
See related:HGNC:8881|MIM:176610|HPRD:01452
Chromosome:17
Location:17p13.3
Gene Description:profilin 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0118
ORGANISM:human
Entrez Gene ID:5216
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:-3.61 :: -2.87 :: -3.21 :: -3.94 :: 0.29 :: 0.58 :: 0.44
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5216GO:0003785NRFunctionactin monomer binding
5216GO:0007010IEAProcesscytoskeleton organization and biogenesis
5216GO:0015629IEAComponentactin cytoskeleton
5216GO:0030036IEAProcessactin cytoskeleton organization and biogenesis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55740NP_001008493.1enabled homolog isoform aHPRD12360
-339344NP_001012661.1Myb protein P42POPHPRD17352
-7408NP_003361.1vasodilator-stimulated phosphoprotein isoform 1HPRD03415
-8976NP_003932.1Wiskott-Aldrich syndrome gene-like proteinHPRD05448
-23433NP_036381.1ras-like protein TC10HPRD05791
-10243NP_065857.1gephyrin isoform 1HPRD04893
NP_005013.18936NP_003922.1Wiskott-Aldrich syndrome protein family member 1HPRD05434
NP_005013.123214NP_055986.1exportin 6HPRD10525
NP_005013.154518NP_061916.3amyloid beta (A4) precursor protein-binding, family B, member 1 interacting proteinHPRD16420
NP_005013.154518NP_061916.3amyloid beta (A4) precursor protein-binding, family B, member 1 interacting proteinBIND185494
NP_005013.1147179NP_573571.1WIRE proteinHPRD18304
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5216PROF1_HUMANP07737IPR002097ProfilinProfilin/allergen
5216PROF1_HUMANP07737IPR005454Profilin_mammalMammalian profilin

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