Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5243
Official Symbol:ABCB1
Other Aliases:ABC20|CD243|CLCS|GP170|MDR1|P-gp|PGY1
See related:HGNC:40|MIM:171050|HPRD:01370
Chromosome:7
Location:7q21.1
Gene Description:ATP-binding cassette, sub-family B (MDR/TAP), member 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0224
ORGANISM:human
Entrez Gene ID:5243
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11093800
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ADMINISTRATION
Addiction Brain Area:SH-SY5Y neuroblastoma cells
Drug Effects:Upregulated
Fold Change:At least 2-folds difference
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18669CBCerebellum0.00.0
18669CTXCerebral cortex0.00.0
18669HIPHippocampal region0.00.0
18669HPFHippocampal formation0.00.0
18669HYHypothalamus0.00.0
18669LSXLateral septal complex0.00.0
18669MBMidbrain0.00.0
18669MYMedulla0.00.0
18669OLFOlfactory bulb0.00.0
18669PPons0.00.0
18669PALPallidum0.00.0
18669RHPRetrohippocampal region0.00.0
18669sAMYStriatum-like amygdalar nuclei0.00.0
18669STRStriatum0.00.0
18669STRdStriatum dorsal region0.00.0
18669STRvStriatum ventral region0.00.0
18669THThalamus0.00.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5243GO:0000166IEAFunctionnucleotide binding
5243GO:0005215TASFunctiontransporter activity
5243GO:0005524TASFunctionATP binding
5243GO:0005624TASComponentmembrane fraction
5243GO:0006810TASProcesstransport
5243GO:0009986IEPComponentcell surface
5243GO:0016020IEAComponentmembrane
5243GO:0016021TASComponentintegral to membrane
5243GO:0016887IEAFunctionATPase activity
5243GO:0042493TASProcessresponse to drug
5243GO:0042626TASFunctionATPase activity, coupled to transmembrane movement of substances
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NC_000007.11---BIND216128
NP_000918.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5243MDR1_HUMANP08183IPR001140ABC_TM_transptABC transporter, transmembrane region
5243MDR1_HUMANP08183IPR003439ABC_transp_likeABC transporter related
5243MDR1_HUMANP08183IPR001687ATP_GTP_BS_AATP/GTP-binding site motif A (P-loop)
5243MDR1_HUMANP08183IPR013563Oligopep_ABC_COligopeptide/dipeptide ABC transporter, C-terminal
5243MDR1_HUMANP08183IPR006082PRKPhosphoribulokinase

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