Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:526
Official Symbol:ATP6V1B2
Other Aliases:ATP6B1B2|ATP6B2|HO57|VATB|VPP3|Vma2
See related:HGNC:854|MIM:606939|HPRD:06088
Chromosome:8
Location:8p22-p21
Gene Description:ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0577
ORGANISM:human
Entrez Gene ID:526
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:117596
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIP0255
ORGANISM:human
Entrez Gene ID:526
Evidence Type:Proteomics
Evidence ID Type:PUBMED
Evidence ID:16172612
Addiction Drug:ALCOHOL
Addiction Drug Detail:Chronic alcohol use
Addiction Brain Area:Brain
Drug Effects:Downregulated
Fold Change:-1.3::-1.5
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11966CBCerebellum81.154457092285278.2750816345215
11966CTXCerebral cortex100.0100.0
11966HIPHippocampal region98.5791244506836100.0
11966HPFHippocampal formation100.0100.0
11966HYHypothalamus100.0100.0
11966LSXLateral septal complex99.046485900878993.5285835266113
11966MBMidbrain100.0100.0
11966MYMedulla100.0100.0
11966OLFOlfactory bulb100.0100.0
11966PPons98.2227935791016100.0
11966PALPallidum100.0100.0
11966RHPRetrohippocampal region100.0100.0
11966sAMYStriatum-like amygdalar nuclei100.0100.0
11966STRStriatum93.602008819580176.817211151123
11966STRdStriatum dorsal region78.764373779296959.6556835174561
11966STRvStriatum ventral region100.096.3881492614746
11966THThalamus87.820014953613392.724437713623
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
526GO:0005524IEAFunctionATP binding
526GO:0005737IEAComponentcytoplasm
526GO:0006811IEAProcession transport
526GO:0008553IEAFunctionhydrogen-exporting ATPase activity, phosphorylative mechanism
526GO:0015986IEAProcessATP synthesis coupled proton transport
526GO:0015988IEAProcessenergy coupled proton transport, against electrochemical gradient
526GO:0016469IEAComponentproton-transporting two-sector ATPase complex
526GO:0016787IEAFunctionhydrolase activity
526GO:0046872IEAFunctionmetal ion binding
526GO:0046933IEAFunctionhydrogen-transporting ATP synthase activity, rotational mechanism
526GO:0046961TASFunctionhydrogen-transporting ATPase activity, rotational mechanism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
526VATB2_HUMANP21281IPR000194ATPase_a_b_nl-bdATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
526VATB2_HUMANP21281IPR000793ATPase_a_b_CATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
526VATB2_HUMANP21281IPR004100ATPase_a_b_NATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal

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