Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:529
Official Symbol:ATP6V1E1
Other Aliases:ATP6E|ATP6E2|ATP6V1E|P31|Vma4
See related:HGNC:857|MIM:108746|HPRD:00163
Chromosome:22
Location:22pter-q11.2|22q11.1
Gene Description:ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0527
ORGANISM:human
Entrez Gene ID:529
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:297566
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0951
ORGANISM:human
Entrez Gene ID:529
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.8
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
11973CBCerebellum83.6769828796387100.0
11973CTXCerebral cortex100.0100.0
11973HIPHippocampal region100.0100.0
11973HPFHippocampal formation100.0100.0
11973HYHypothalamus100.0100.0
11973LSXLateral septal complex100.0100.0
11973MBMidbrain100.0100.0
11973MYMedulla100.0100.0
11973OLFOlfactory bulb100.0100.0
11973PPons99.4488220214844100.0
11973PALPallidum100.0100.0
11973RHPRetrohippocampal region100.0100.0
11973sAMYStriatum-like amygdalar nuclei100.0100.0
11973STRStriatum100.0100.0
11973STRdStriatum dorsal region100.0100.0
11973STRvStriatum ventral region100.0100.0
11973THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
529GO:0005515IPIFunctionprotein binding
529GO:0005886NRComponentplasma membrane
529GO:0006811IEAProcession transport
529GO:0015986IEAProcessATP synthesis coupled proton transport
529GO:0015992TASProcessproton transport
529GO:0016469IEAComponentproton-transporting two-sector ATPase complex
529GO:0016469TASComponentproton-transporting two-sector ATPase complex
529GO:0016787IEAFunctionhydrolase activity
529GO:0046872IEAFunctionmetal ion binding
529GO:0046933IEAFunctionhydrogen-transporting ATP synthase activity, rotational mechanism
529GO:0046961IEAFunctionhydrogen-transporting ATPase activity, rotational mechanism
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9368NP_004243.1solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1HPRD05406
-6654NP_005624.2son of sevenless homolog 1HPRD01681
NP_001687.1--V ATPase Subunit HHPRD00163
NP_001687.19368-Solute carrier family 9, isoform A3, regulatory factor 1HPRD00163
NP_001687.16654-SOS1HPRD00163
NP_001687.151606NP_998785.1ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 2HPRD10591
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
529VATE_HUMANP36543IPR002842ATPase_V1/A1_EATPase, V1/A1 complex, subunit E

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