Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5315
Official Symbol:PKM2
Other Aliases:CTHBP|MGC3932|OIP3|PK3|PKM|TCB|THBP1
See related:HGNC:9021|MIM:179050|HPRD:01529
Chromosome:15
Location:15q22
Gene Description:pyruvate kinase, muscle
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0087
ORGANISM:human
Entrez Gene ID:5315
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18746
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIC0503
ORGANISM:human
Entrez Gene ID:5315
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25630
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18746CBCerebellum35.6995620727539100.0
18746CTXCerebral cortex100.0100.0
18746HIPHippocampal region100.0100.0
18746HPFHippocampal formation100.0100.0
18746HYHypothalamus100.0100.0
18746LSXLateral septal complex100.0100.0
18746MBMidbrain73.0837783813477100.0
18746MYMedulla24.850311279296960.314079284668
18746OLFOlfactory bulb89.8960113525391100.0
18746PPons45.4786605834961100.0
18746PALPallidum100.0100.0
18746RHPRetrohippocampal region100.0100.0
18746sAMYStriatum-like amygdalar nuclei100.0100.0
18746STRStriatum100.0100.0
18746STRdStriatum dorsal region100.0100.0
18746STRvStriatum ventral region100.0100.0
18746THThalamus100.0100.0
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5315GO:0000287IEAFunctionmagnesium ion binding
5315GO:0004743IEAFunctionpyruvate kinase activity
5315GO:0004743TASFunctionpyruvate kinase activity
5315GO:0005515IPIFunctionprotein binding
5315GO:0005829NASComponentcytosol
5315GO:0006096IEAProcessglycolysis
5315GO:0006096NASProcessglycolysis
5315GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002645.35894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND193143
NP_002645.35894NP_002871.1v-raf-1 murine leukemia viral oncogene homolog 1BIND217457
NP_872270.1--RRP46HPRD01529
NP_872270.15894-RAF1HPRD01529
NP_872270.156915NP_064543.3exosome component Rrp46HPRD16222
NP_872270.18470NP_066547.1sorbin and SH3 domain containing 2 isoform 2HPRD12473
NP_872270.18470NP_066547.1sorbin and SH3 domain containing 2 isoform 2HPRD01529
NP_872270.15315NP_872270.1pyruvate kinase 3 isoform 2HPRD01529
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5315IPR001697Pyruvate_kinasePyruvate kinase
5315KPYM_HUMANP14618IPR001697Pyruvate_kinasePyruvate kinase

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