Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5319
Official Symbol:PLA2G1B
Other Aliases:MGC119834|MGC119835|PLA2|PLA2A|PPLA2
See related:HGNC:9030|MIM:172410|HPRD:01396
Chromosome:12
Location:12q23-q24.1
Gene Description:phospholipase A2, group IB (pancreas)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0485
ORGANISM:human
Entrez Gene ID:5319
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:29526
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0410
ORGANISM:human
Entrez Gene ID:5319
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.5 :: 1.2 :: 1.2 :: 1.9 :: -1.1 :: 1.4
KARG Evidence 3
KARG ID:EVIM0478
ORGANISM:human
Entrez Gene ID:5319
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.4 :: 1.6 :: 1.4 :: 1.8 :: 1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18778CBCerebellum0.3420346975326541.11244773864746
18778CTXCerebral cortex0.2951320111751560.633822083473206
18778HIPHippocampal region0.299961328506471.13979399204254
18778HPFHippocampal formation0.2620957195758820.895298421382904
18778HYHypothalamus0.4315916001796720.456261247396469
18778LSXLateral septal complex0.1700016260147090.153552636504173
18778MBMidbrain0.2982258498668670.44563814997673
18778MYMedulla0.7016175389289860.852026224136353
18778OLFOlfactory bulb0.4822471737861631.58789825439453
18778PPons0.214529842138290.353428393602371
18778PALPallidum0.1954382956027980.206351041793823
18778RHPRetrohippocampal region0.1887847483158110.537315011024475
18778sAMYStriatum-like amygdalar nuclei0.09772179275751110.0691374912858009
18778STRStriatum0.2335653603076930.261519759893417
18778STRdStriatum dorsal region0.2031074762344360.26939782500267
18778STRvStriatum ventral region0.3463062047958370.237911596894264
18778THThalamus0.7342866063117980.671506345272064
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5319GO:0004623IEAFunctionphospholipase A2 activity
5319GO:0004623TASFunctionphospholipase A2 activity
5319GO:0005509IEAFunctioncalcium ion binding
5319GO:0007015TASProcessactin filament organization
5319GO:0007165TASProcesssignal transduction
5319GO:0016042IEAProcesslipid catabolism
5319GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-9373NP_004244.1phospholipase A2-activating protein isoform 2HPRD04850
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5319PA21B_HUMANP04054IPR001211PhospholipaseA2Phospholipase A2
5319PA21B_HUMANP04054IPR013090Phospholip_A2_ASPhospholipase A2, active site

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