Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5328
Official Symbol:PLAU
Other Aliases:ATF|UPA|URK|u-PA
See related:HGNC:9052|MIM:191840|HPRD:01883
Chromosome:10
Location:10q24
Gene Description:plasminogen activator, urokinase
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0421
ORGANISM:human
Entrez Gene ID:5328
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25619
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18792CBCerebellum2.802902221679694.08394002914429
18792CTXCerebral cortex1.254339575767521.01703763008118
18792HIPHippocampal region0.6631247997283940.704993963241577
18792HPFHippocampal formation1.104312300682071.03602170944214
18792HYHypothalamus0.1340712904930110.122457079589367
18792LSXLateral septal complex0.07393278926610950.0
18792MBMidbrain0.4122730195522310.524610042572021
18792MYMedulla1.895010590553282.21716785430908
18792OLFOlfactory bulb1.340617895126342.08398222923279
18792PPons1.467192053794861.92857885360718
18792PALPallidum0.2899513244628910.275500446557999
18792RHPRetrohippocampal region1.744189143180851.4231823682785
18792sAMYStriatum-like amygdalar nuclei0.2775029540061950.318224281072617
18792STRStriatum0.5475870966911320.432021975517273
18792STRdStriatum dorsal region0.3239983618259430.281846940517426
18792STRvStriatum ventral region1.744107365608221.12871992588043
18792THThalamus0.4684664309024810.483717024326324
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5328GO:0004252IEAFunctionserine-type endopeptidase activity
5328GO:0005615NRComponentextracellular space
5328GO:0006508IEAProcessproteolysis
5328GO:0006508TASProcessproteolysis
5328GO:0006935TASProcesschemotaxis
5328GO:0007165TASProcesssignal transduction
5328GO:0007596IEAProcessblood coagulation
5328GO:0008233IEAFunctionpeptidase activity
5328GO:0008243IEAFunctionplasminogen activator activity
5328GO:0016301IEAFunctionkinase activity
5328GO:0042730IEAProcessfibrinolysis
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
NP_002649.15340-PlasminogenHPRD01883
NP_002649.15329NP_002650.1plasminogen activator, urokinase receptor isoform 1 precursorHPRD01883
NP_002649.15329NP_002650.1plasminogen activator, urokinase receptor isoform 1 precursorHPRD01883
NP_002649.1155030NP_057850.1Pr55(Gag)--
NP_002649.1155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5328UROK_HUMANP00749IPR000742EGF_3EGF-like, type 3
5328UROK_HUMANP00749IPR013032EGF_like_regEGF-like region
5328UROK_HUMANP00749IPR000001KringleKringle
5328UROK_HUMANP00749IPR001254Peptidase_S1_S6Peptidase S1 and S6, chymotrypsin/Hap
5328UROK_HUMANP00749IPR001314Peptidase_S1APeptidase S1A, chymotrypsin

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