Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5335
Official Symbol:PLCG1
Other Aliases:PLC-II|PLC1|PLC148|PLCgamma1
See related:HGNC:9065|MIM:172420|HPRD:01398
Chromosome:20
Location:20q12-q13.1
Gene Description:phospholipase C, gamma 1
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0525
ORGANISM:human
Entrez Gene ID:5335
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25738
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18803CBCerebellum42.839565277099653.4993362426758
18803CTXCerebral cortex100.084.2481307983398
18803HIPHippocampal region64.286872863769597.8827209472656
18803HPFHippocampal formation73.633979797363388.4461669921875
18803HYHypothalamus44.955886840820333.8219146728516
18803LSXLateral septal complex69.700599670410248.9651947021484
18803MBMidbrain56.172107696533249.3547477722168
18803MYMedulla56.005435943603554.6938056945801
18803OLFOlfactory bulb86.32213592529375.7400588989258
18803PPons47.856376647949244.9561653137207
18803PALPallidum60.687763214111354.6177368164062
18803RHPRetrohippocampal region92.781272888183677.2698059082031
18803sAMYStriatum-like amygdalar nuclei93.360763549804771.1731948852539
18803STRStriatum79.054359436035260.1169013977051
18803STRdStriatum dorsal region79.065444946289161.5009651184082
18803STRvStriatum ventral region77.104125976562554.9340744018555
18803THThalamus57.316860198974648.6691284179688
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5335GO:0004435NASFunctionphosphoinositide phospholipase C activity
5335GO:0005057NASFunctionreceptor signaling protein activity
5335GO:0005509IEAFunctioncalcium ion binding
5335GO:0005515IPIFunctionprotein binding
5335GO:0007242IEAProcessintracellular signaling cascade
5335GO:0008372NDComponentcellular component unknown
5335GO:0016042IEAProcesslipid catabolism
5335GO:0016787IEAFunctionhydrolase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-7454NP_000368.1Wiskott-Aldrich syndrome proteinHPRD02314
-6401NP_000441.1selectin E precursorHPRD00566
-5338NP_002654.2phospholipase D2HPRD03857
-5587NP_002733.1protein kinase D1HPRD05668
-6452NP_003014.2SH3-domain binding protein 2HPRD03657
-6850NP_003168.2spleen tyrosine kinaseHPRD02514
-7222NP_003296.1transient receptor potential cation channel, subfamily C, member 3HPRD15999
-7275NP_003311.2tubby isoform aHPRD03121
-8660NP_003740.2insulin receptor substrate 2HPRD02878
-9531NP_004272.2BCL2-associated athanogene 3HPRD04860
-6714NP_005408.1proto-oncogene tyrosine-protein kinase SRCHPRD01819
-7409NP_005419.2vav 1 oncogeneHPRD01284
-5747NP_005598.3PTK2 protein tyrosine kinase 2 isoform bHPRD02859
-6654NP_005624.2son of sevenless homolog 1HPRD01681
-10451NP_006104.3vav 3 oncogeneHPRD05706
-5586NP_006247.1protein kinase N2HPRD03972
-10657NP_006550.1KH domain containing, RNA binding, signal transduction associated 1HPRD03926
-6655NP_008870.1son of sevenless homolog 2HPRD03149
-6853NP_008881.2synapsin I isoform IaHPRD02433
-8301NP_009097.1phosphatidylinositol-binding clathrin assembly proteinHPRD04320
-27040NP_055202.1linker for activation of T cells isoform aHPRD03832
-27040NP_055202.1linker for activation of T cells isoform aBIND216525
-9743NP_055530.2Rho GTPase-activating proteinHPRD12257
-9892NP_055656.1synaptosomal-associated protein, 91kDa homologHPRD06391
-54822NP_060142.2transient receptor potential cation channel, subfamily M, member 7HPRD10418
-58480NP_067028.1ras homolog gene family, member UBIND185152
-7462NP_071323.1linker for activation of T cells family member 2HPRD09304
-7222Q13507Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).BIND216877
-8525Q13574Diacylglycerol kinase zeta (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).HPRD03260
NP_002651.15336AAH11772.1PLCG2 proteinHPRD02570
NP_002651.15795NP_002834.2protein tyrosine phosphatase, receptor type, J precursorHPRD02955
NP_002651.16461NP_003019.1SHB (Src homology 2 domain containing) adaptor protein BHPRD02635
NP_002651.18615NP_003706.1vesicle docking protein p115HPRD09135
NP_002651.18711NP_003976.1tyrosine kinase, non-receptor, 1HPRD09730
NP_002651.128964NP_054749.1G protein-coupled receptor kinase-interactor 1HPRD06577
NP_002651.15979NP_066124.1ret proto-oncogene isoform aHPRD01266
NP_002651.2--p62HPRD01398
NP_002651.2-NP_000314.1ret proto-oncogene isoform aBIND57631
NP_002651.26714-c-SrcHPRD01398
NP_002651.27535-ZAP70HPRD01398
NP_002651.210399-RACK1HPRD01398
NP_002651.25747-FAKHPRD01398
NP_002651.25587-Protein kinase C, muHPRD01398
NP_002651.26850-SYKHPRD01398
NP_002651.27454-Wiskott-aldrich syndrome proteinHPRD01398
NP_002651.25586-Protein kinase C like 2HPRD01398
NP_002651.28660-IRS2HPRD01398
NP_002651.227040-Linker for activation of T cellsHPRD01398
NP_002651.210657-Sam68HPRD01398
NP_002651.27409-VAV1HPRD01398
NP_002651.27275-TUBHPRD01398
NP_002651.26853-Synapsin IHPRD01398
NP_002651.26654-SOS1HPRD01398
NP_002651.28301-CALMHPRD01398
NP_002651.26655-SOS2HPRD01398
NP_002651.29531-BCL2 associated athanogene 3HPRD01398
NP_002651.210451-VAV3HPRD01398
NP_002651.26452-SH3 domain binding protein 2HPRD01398
NP_002651.29892-Synaptosomal associated protein, 91 kDHPRD01398
NP_002651.2116986-Phosphoinositide 3 kinase enhancerHPRD01398
NP_002651.254822-Transient receptor potential cation channel, subfamily M, member 7HPRD01398
NP_002651.29743-RICSHPRD01398
NP_002651.27462-Williams-Beuren syndrome chromosome region 5HPRD01398
NP_002651.25338-Phospholipase D2HPRD01398
NP_002651.28525-Diacylglycerol kinase, zetaHPRD01398
NP_002651.26401-Selectin EHPRD01398
NP_002651.27222-Transient receptor potential cation channel, subfamily C, member 3HPRD01398
NP_002651.25336AAH11772.1PLCG2 proteinHPRD01398
NP_002651.25338NP_002654.2phospholipase D2BIND146128
NP_002651.25795NP_002834.2protein tyrosine phosphatase, receptor type, J precursorHPRD01398
NP_002651.26461NP_003019.1SHB (Src homology 2 domain containing) adaptor protein BHPRD01398
NP_002651.228964NP_054749.1G protein-coupled receptor kinase-interactor 1HPRD01398
NP_002651.230837NP_055413.1suppressor of cytokine signaling 7HPRD01398
NP_002651.230837NP_055413.1suppressor of cytokine signaling 7HPRD12299
NP_002651.25979NP_065681.1ret proto-oncogene isoform cBIND57632
NP_002651.25979NP_066124.1ret proto-oncogene isoform aHPRD01398
NP_002651.25979NP_066124.1ret proto-oncogene isoform aHPRD01266
NP_002651.2155871NP_057853.1Tat--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5335IPR000008C2C2
5335IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
5335IPR001849PHPleckstrin-like
5335IPR001192PI_PLCPhosphoinositide-specific phospholipase C (PLC)
5335IPR000909PI_PLC_XPhosphatidylinositol-specific phospholipase C, X region
5335IPR001711PI_PLC_YPhosphatidylinositol-specific phospholipase C, Y domain
5335IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
5335IPR013625PTBTensin phosphotyrosine-binding domain
5335IPR000980SH2SH2 motif
5335IPR001452SH3Src homology-3
5335IPR011511SH3_2Variant SH3
5335PLCG1_HUMANP19174IPR000008C2C2
5335PLCG1_HUMANP19174IPR002048EF_hand_Ca_bdCalcium-binding EF-hand
5335PLCG1_HUMANP19174IPR001849PHPleckstrin-like
5335PLCG1_HUMANP19174IPR001192PI_PLCPhosphoinositide-specific phospholipase C (PLC)
5335PLCG1_HUMANP19174IPR000909PI_PLC_XPhosphatidylinositol-specific phospholipase C, X region
5335PLCG1_HUMANP19174IPR001711PI_PLC_YPhosphatidylinositol-specific phospholipase C, Y domain
5335PLCG1_HUMANP19174IPR013583PRT_C_plnPhosphoribosyltransferase C-terminal, plant
5335PLCG1_HUMANP19174IPR013625PTBTensin phosphotyrosine-binding domain
5335PLCG1_HUMANP19174IPR000980SH2SH2 motif
5335PLCG1_HUMANP19174IPR001452SH3Src homology-3
5335PLCG1_HUMANP19174IPR011511SH3_2Variant SH3

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