Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5338
Official Symbol:PLD2
Other Aliases:-
See related:HGNC:9068|MIM:602384|HPRD:03857
Chromosome:17
Location:17p13.1
Gene Description:phospholipase D2
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0504
ORGANISM:human
Entrez Gene ID:5338
Evidence Type:Mapping from rat
Evidence ID Type:Entrez Gene
Evidence ID:25097
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18806CBCerebellum25.110334396362327.0976829528809
18806CTXCerebral cortex47.453666687011734.2940902709961
18806HIPHippocampal region32.705558776855538.0728569030762
18806HPFHippocampal formation37.499179840087936.9354286193848
18806HYHypothalamus56.843009948730543.9877395629883
18806LSXLateral septal complex49.542728424072336.1442184448242
18806MBMidbrain45.807563781738340.4595909118652
18806MYMedulla61.682655334472763.9401931762695
18806OLFOlfactory bulb87.807197570800872.1576690673828
18806PPons51.844524383544955.9479637145996
18806PALPallidum43.848411560058636.4913864135742
18806RHPRetrohippocampal region49.293754577636736.9366683959961
18806sAMYStriatum-like amygdalar nuclei63.63031387329147.859432220459
18806STRStriatum47.624610900878933.7403144836426
18806STRdStriatum dorsal region41.667320251464829.0052700042725
18806STRvStriatum ventral region60.069538116455141.2511100769043
18806THThalamus40.568984985351631.9721927642822
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5338GO:0004630TASFunctionphospholipase D activity
5338GO:0005515IEAFunctionprotein binding
5338GO:0005886TASComponentplasma membrane
5338GO:0007010TASProcesscytoskeleton organization and biogenesis
5338GO:0007264TASProcesssmall GTPase mediated signal transduction
5338GO:0008152IEAProcessmetabolism
5338GO:0016042IEAProcesslipid catabolism
5338GO:0016787IEAFunctionhydrolase activity
5338GO:0035091IEAFunctionphosphoinositide binding
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-8682NP_003759.1phosphoprotein enriched in astrocytes 15HPRD04579
NP_002654.2--Alpha actininHPRD03857
NP_002654.2--Aldolase CHPRD03857
NP_002654.28682-PEA15HPRD03857
NP_002654.25578-Protein kinase C alphaHPRD03857
NP_002654.25580-Protein kinase C deltaHPRD03857
NP_002654.28394AAC50911.1Human 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha mRNA, clone PIP5KIa2, and translated productsHPRD03857
NP_002654.28394AAC50911.1Human 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha mRNA, clone PIP5KIa2, and translated productsHPRD04470
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5338PLD2_HUMANO14939IPR001849PHPleckstrin-like
5338PLD2_HUMANO14939IPR001736PLDPhospholipase D/Transphosphatidylase
5338PLD2_HUMANO14939IPR001683PXPhox-like

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