Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5347
Official Symbol:PLK1
Other Aliases:PLK|STPK13
See related:HGNC:9077|MIM:602098|HPRD:03652
Chromosome:16
Location:16p12.1
Gene Description:polo-like kinase 1 (Drosophila)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0920
ORGANISM:human
Entrez Gene ID:5347
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:1.4 :: 1.6
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18817CBCerebellum87.199825286865284.5393524169922
18817CTXCerebral cortex89.616275787353572.2615528106689
18817HIPHippocampal region85.809913635253972.5228328704834
18817HPFHippocampal formation89.940608978271575.2044010162354
18817HYHypothalamus79.529373168945368.0899448394775
18817LSXLateral septal complex60.258557319641155.8295578956604
18817MBMidbrain89.159889221191476.3920593261719
18817MYMedulla97.354721069335994.387825012207
18817OLFOlfactory bulb100.079.9107093811035
18817PPons93.045158386230586.8284683227539
18817PALPallidum71.463642120361365.1169128417969
18817RHPRetrohippocampal region97.702590942382880.4953327178955
18817sAMYStriatum-like amygdalar nuclei81.303073883056665.9519290924072
18817STRStriatum71.255836486816461.1946458816528
18817STRdStriatum dorsal region68.15219306945859.3711767196655
18817STRvStriatum ventral region82.971389770507867.2592468261719
18817THThalamus88.06597518920979.237325668335
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5347GO:0000074TASProcessregulation of progression through cell cycle
5347GO:0000166IEAFunctionnucleotide binding
5347GO:0004674IEAFunctionprotein serine/threonine kinase activity
5347GO:0004674TASFunctionprotein serine/threonine kinase activity
5347GO:0005515IEAFunctionprotein binding
5347GO:0005515IPIFunctionprotein binding
5347GO:0005524IEAFunctionATP binding
5347GO:0005634IEAComponentnucleus
5347GO:0006468IEAProcessprotein amino acid phosphorylation
5347GO:0007067TASProcessmitosis
5347GO:0008283TASProcesscell proliferation
5347GO:0016740IEAFunctiontransferase activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-10726NP_006591.1nuclear distribution gene C homolog (A. nidulans)HPRD10122
-11200NP_009125.1protein kinase CHK2 isoform aHPRD05084
-259266NP_060606.2asp (abnormal spindle)-like, microcephaly associatedHPRD08384
-64689NP_114105.1Golgi reassembly stacking protein 1HPRD06038
-9493NP_612565.1kinesin family member 23 isoform 1HPRD05455
NP_005021.2--Alpha tubulinHPRD03652
NP_005021.2--Beta tubulinHPRD03652
NP_005021.2--Gamma tubulinHPRD03652
NP_005021.2--Proteasome subunit alpha C2HPRD03652
NP_005021.2--Proteasome subunit alpha C8HPRD03652
NP_005021.2--Proteasome subunit alpha C9HPRD03652
NP_005021.2--Proteasome subunit alpha iotaHPRD03652
NP_005021.2--Proteasome subunit beta N3HPRD03652
NP_005021.2--Proteasome subunit beta XHPRD03652
NP_005021.2--Proteasome subunit beta YHPRD03652
NP_005021.2--Proteasome subunit beta ZHPRD03652
NP_005021.2--Proteasome subunit beta c10HPRD03652
NP_005021.2--Proteasome subunit beta c7HPRD03652
NP_005021.2---BIND201946
NP_005021.29493-KIF23HPRD03652
NP_005021.25684-Proteasome subunit, alpha type 3HPRD03652
NP_005021.2259266-ASPMHPRD03652
NP_005021.264689-Golgi reassembly stacking protein 1HPRD03652
NP_005021.211200-CHK2HPRD03652
NP_005021.210726-NUDCHPRD03652
NP_005021.25685NP_002780.1proteasome alpha 4 subunitHPRD10168
NP_005021.25686NP_002781.1proteasome (prosome, macropain) subunit, alpha type, 5HPRD03652
NP_005021.25688NP_002783.1proteasome alpha 7 subunitHPRD03652
NP_005021.25688NP_002783.1proteasome alpha 7 subunitHPRD05967
NP_005021.25689NP_002784.1proteasome beta 1 subunitHPRD03603
NP_005021.25689NP_002784.1proteasome beta 1 subunitHPRD03652
NP_005021.27465NP_003381.1wee1 tyrosine kinaseBIND216077
NP_005021.29600NP_004901.1phosphatidylinositol transfer protein, membrane-associatedBIND134114
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5347PLK1_HUMANP53350IPR013543CaMKII_ADCalcium/calmodulin dependent protein kinase II, association-domain
5347PLK1_HUMANP53350IPR003279KIR62_channelKir6.2 inward rectifier K+ channel
5347PLK1_HUMANP53350IPR000959POLO_boxPOLO box duplicated region
5347PLK1_HUMANP53350IPR000719Prot_kinaseProtein kinase
5347PLK1_HUMANP53350IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active site
5347PLK1_HUMANP53350IPR001245Tyr_pkinaseTyrosine protein kinase
5347PLK1_HUMANP53350IPR013695WAKWall-associated kinase

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