Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5354
Official Symbol:PLP1
Other Aliases:MMPL|PLP|PLP/DM20|PMD|SPG2
See related:HGNC:9086|MIM:300401|HPRD:02321
Chromosome:X
Location:Xq22
Gene Description:proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIC0278
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Mapping from mouse
Evidence ID Type:Entrez Gene
Evidence ID:18823
Addiction Drug:
Addiction Drug Detail:
Addiction Brain Area:
Drug Effects:
Fold Change:
KARG Evidence 2
KARG ID:EVIM0072
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15009677
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Nucleus Accumbens
Drug Effects:Downregulated
Fold Change:-1.43 :: -0.73 :: 0.23 :: -0.93 :: -0.27 :: -0.32 :: 0.20 :: 0.07 :: 0.15 :: -0.66
KARG Evidence 3
KARG ID:EVIM0127
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12629581
Addiction Drug:COCAINE
Addiction Drug Detail:COCAINE ABUSE
Addiction Brain Area:Dorsolateral Prefrontal Cortex
Drug Effects:Upregulated/Downregulated
Fold Change:2.34 :: 1.50 :: 0.53 :: 1.80 :: -4.06 :: -3.04 :: -6.69
KARG Evidence 4
KARG ID:EVIM0165
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:superior frontal gyrus
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 5
KARG ID:EVIM0170
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:16205370
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:-
KARG Evidence 6
KARG ID:EVIM0386
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Upregulated
Fold Change:-1.9 :: -1.4 :: 5 :: 2.1 :: 4.1 :: 1.5
KARG Evidence 7
KARG ID:EVIM0454
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:12065639
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Motor Cortex
Drug Effects:Downregulated
Fold Change:1.5 :: 1.6 :: -1.2 :: 3.7 :: 1.1
KARG Evidence 8
KARG ID:EVIM0818
ORGANISM:human
Entrez Gene ID:5354
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:11141048
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Frontal Cortex
Drug Effects:Downregulated
Fold Change:-2.1 :: -1.9 :: -2.1 :: -1.3
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18823CBCerebellum93.034157843816895.7886694499424
18823CTXCerebral cortex95.732628958565995.9023798079718
18823HIPHippocampal region87.989613760085395.8720231737409
18823HPFHippocampal formation94.555150259108895.9487854639689
18823HYHypothalamus96.273077737717495.6632323946272
18823LSXLateral septal complex97.010589236304995.9258926482428
18823MBMidbrain96.167921157110395.7232148760841
18823MYMedulla96.420852842785195.9467311132522
18823OLFOlfactory bulb96.773152487618695.9881893793742
18823PPons96.272674106416295.7945764178321
18823PALPallidum95.932046617780495.6301347641718
18823RHPRetrohippocampal region97.276385534377396.1002705891927
18823sAMYStriatum-like amygdalar nuclei93.970170225415995.3482715742929
18823STRStriatum96.224655877976295.6020088422866
18823STRdStriatum dorsal region96.131048384166995.5607125418527
18823STRvStriatum ventral region93.894632248651495.7135591961089
18823THThalamus96.282036463419695.7103647050403
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5354GO:0005198IEAFunctionstructural molecule activity
5354GO:0016020IEAComponentmembrane
5354GO:0016021IEAComponentintegral to membrane
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5354IPR001614Myelin_PLPMyelin proteolipid protein PLP
5354MYPR_HUMANP60201IPR001614Myelin_PLPMyelin proteolipid protein PLP

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