Knowledgebase for Addiction-Related Genes
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KARG (Knowledgebase for Addiction Related Genes) >> Gene Entry 
For each addiction related gene, evidences from various strategies have been listed in detail. In addition, each gene were further annotated with various online databases including basic information, gene ontology annotation, protein interaction and domain information.

Basic Information
Gene ID:5371
Official Symbol:PML
Other Aliases:MYL|PP8675|RNF71|TRIM19
See related:HGNC:9113|MIM:102578|HPRD:00023
Chromosome:15
Location:15q22
Gene Description:promyelocytic leukemia
Gene type:protein-coding
Gene Structure:
Genomic Context:
KARG Evidence 1
KARG ID:EVIM0244
ORGANISM:human
Entrez Gene ID:5371
Evidence Type:Microarray
Evidence ID Type:PUBMED
Evidence ID:15816859
Addiction Drug:ALCOHOL
Addiction Drug Detail:ALCOHOL ABUSE
Addiction Brain Area:Prefrontal Cortex
Drug Effects:Upregulated
Fold Change:0.67
Mapped Allen Brain Atlas (Click to check expression images in Allan Brain Atlas)
Mouse Entrez Gene IDBrain RegionBrain Region DetailExpression LevelExpression Density
18854CBCerebellum2.08669734001162.7791965007782
18854CTXCerebral cortex0.4794259667396550.706497550010681
18854HIPHippocampal region0.8981358408927921.54224967956543
18854HPFHippocampal formation1.002516627311711.54980504512787
18854HYHypothalamus1.659513354301452.14429879188538
18854LSXLateral septal complex0.3963800072669980.482593268156052
18854MBMidbrain0.6847043037414551.45772159099579
18854MYMedulla1.045581340789791.9435909986496
18854OLFOlfactory bulb4.063733100891115.65964078903198
18854PPons2.153873443603524.37940788269043
18854PALPallidum0.597860574722291.77204024791718
18854RHPRetrohippocampal region1.13761436939241.36800456047058
18854sAMYStriatum-like amygdalar nuclei0.2412931472063060.432424902915955
18854STRStriatum0.6210065484046940.970821738243103
18854STRdStriatum dorsal region0.1709631085395810.325380355119705
18854STRvStriatum ventral region2.259284973144532.75715303421021
18854THThalamus0.2526257932186130.318075478076935
Gene Ontology
Gene IDGO IDEvidenceGO TypeGO Description
5371GO:0000082IMPProcessG1/S transition of mitotic cell cycle
5371GO:0003676NASFunctionnucleic acid binding
5371GO:0003700TASFunctiontranscription factor activity
5371GO:0003713ISSFunctiontranscription coactivator activity
5371GO:0003824IEAFunctioncatalytic activity
5371GO:0005509IEAFunctioncalcium ion binding
5371GO:0005515IEAFunctionprotein binding
5371GO:0005515IPIFunctionprotein binding
5371GO:0005622IEAComponentintracellular
5371GO:0005622NASComponentintracellular
5371GO:0005626IDAComponentinsoluble fraction
5371GO:0005634IDAComponentnucleus
5371GO:0005654IDAComponentnucleoplasm
5371GO:0005654TASComponentnucleoplasm
5371GO:0006281IDAProcessDNA repair
5371GO:0006350IEAProcesstranscription
5371GO:0006355IEAProcessregulation of transcription, DNA-dependent
5371GO:0006461IDAProcessprotein complex assembly
5371GO:0006915NASProcessapoptosis
5371GO:0006917IMPProcessinduction of apoptosis
5371GO:0006977ISSProcessDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
5371GO:0007050IMPProcesscell cycle arrest
5371GO:0007569IMPProcesscell aging
5371GO:0008270IEAFunctionzinc ion binding
5371GO:0008270NASFunctionzinc ion binding
5371GO:0016363TASComponentnuclear matrix
5371GO:0016564IDAFunctiontranscriptional repressor activity
5371GO:0016605IDAComponentPML body
5371GO:0016605TASComponentPML body
5371GO:0030308IDAProcessnegative regulation of cell growth
5371GO:0030308IMPProcessnegative regulation of cell growth
5371GO:0031065IDAProcesspositive regulation of histone deacetylation
5371GO:0042771ISSProcessDNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
5371GO:0046872IEAFunctionmetal ion binding
5371GO:0046982IDAFunctionprotein heterodimerization activity
Interaction Information
Gene Product IDInteractant Gene IDInteractant Gene Product IDInteractant Gene Product NameSourceSource ID
-55743AAF91084.1Homo sapiens cell cycle checkpoint protein CHFR mRNA, complete cds.HPRD05552
-140691AAH47945.1Ring finger protein 36, isoform aHPRD11518
-5925NP_000312.1retinoblastoma 1HPRD01574
-7157NP_000537.2tumor protein p53HPRD01859
-5914NP_000955.1retinoic acid receptor, alpha isoform aHPRD06769
-6497NP_003027.1v-ski sarcoma viral oncogene homologHPRD01271
-6722NP_003122.1serum response factor (c-fos serum response element-binding transcription factor)HPRD02788
-6996NP_003202.2thymine-DNA glycosylaseHPRD03251
-7048NP_003233.2transforming growth factor, beta receptor II (70/80kDa)HPRD01823
-7067NP_003241.2thyroid hormone receptor, alpha isoform 2HPRD07185
-7046NP_004603.1transforming growth factor, beta receptor I precursorHPRD01822
-9372NP_004790.1MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor isoform 3HPRD04782
-7161NP_005418.1tumor protein p73HPRD03587
-9611NP_006302.2nuclear receptor co-repressor 1HPRD02911
-9612NP_006303.1nuclear receptor co-repressor 2HPRD02910
-6613NP_008868.2SMT3 suppressor of mif two 3 homolog 2HPRD04332
-8805NP_056989.2transcriptional intermediary factor 1 alpha isoform aHPRD04556
-55743NP_060693.1checkpoint with forkhead and ring finger domainsBIND182840
-26287NP_065082.2ankyrin repeat domain 2HPRD12460
-59343NP_067640.1SUMO1/sentrin/SMT3 specific protease 2HPRD07002
-5970NP_068810.1v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65HPRD01241
-6667NP_612482.2Sp1 transcription factorHPRD01796
-6774NP_644805.1signal transducer and activator of transcription 3 isoform 1HPRD00026
AAB19601.26790--BIND216892
NP_002666.16135NP_000966.2ribosomal protein L11BIND149023
NP_002666.17048NP_003233.3transforming growth factor, beta receptor IIBIND171687
NP_002666.17046NP_004603.1transforming growth factor, beta receptor I precursorBIND171686
NP_002666.19372NP_004790.2zinc finger, FYVE domain containing 9 isoform 3BIND171683
NP_150241.1--PLZFHPRD00023
NP_150241.1--RFPHPRD00023
NP_150241.1--Histone deacetylase 3HPRD00023
NP_150241.1--mSin3AHPRD00023
NP_150241.1--RNF36HPRD00023
NP_150241.1--Nucleolar protein L11HPRD00023
NP_150241.15925-Retinoblastoma 1HPRD00023
NP_150241.16613-Sentrin 2HPRD00023
NP_150241.16667-Transcription factor Sp1HPRD00023
NP_150241.17067-Thyroid hormone receptor alphaHPRD00023
NP_150241.18805-Transcriptional intermediary factor 1, alphaHPRD00023
NP_150241.17157-p53HPRD00023
NP_150241.16497-C SkiHPRD00023
NP_150241.19611-Nuclear receptor corepressor 1HPRD00023
NP_150241.19612-Nuclear receptor corepressor 2HPRD00023
NP_150241.17161-p73HPRD00023
NP_150241.159343-Sentrin specific protease 2HPRD00023
NP_150241.16774-STAT3HPRD00023
NP_150241.15970-NFKB3HPRD00023
NP_150241.16722-Serum response factorHPRD00023
NP_150241.15914-Retinoic acid receptor alphaHPRD00023
NP_150241.17046-TGF beta receptor, type IHPRD00023
NP_150241.17048-TGF beta receptor, type IIHPRD00023
NP_150241.19372-MADH interacting proteinHPRD00023
NP_150241.155743-Checkpoint protein with FHA and ring finger domainsHPRD00023
NP_150241.16996-Thymine DNA GlycosylaseHPRD00023
NP_150241.17341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorHPRD00023
NP_150241.17341NP_003343.1SMT3 suppressor of mif two 3 homolog 1 isoform a precursorHPRD03554
NP_150241.17704NP_005997.2promyelocytic leukemia zinc finger proteinHPRD11762
NP_150241.15987NP_006501.1ret finger protein isoform alphaHPRD15996
NP_150241.111073NP_008958.1topoisomerase (DNA) II binding protein 1HPRD09678
NP_150241.111073NP_008958.1topoisomerase (DNA) II binding protein 1HPRD00023
NP_150241.1155871NP_057853.1Tat--
NP_150241.1155348NP_705928.1integrase--
Domain Information
Gene IDUniprot/Swissprot IDUniprot/Swissprot ACCInterpro IDInterpro Short DescriptionInterpro Long Description
5371IPR000694PRO_richProline-rich region
5371IPR000315Znf_BboxZinc finger, B-box
5371IPR001841Znf_RINGZinc finger, RING-type
5371PML_HUMANP29590IPR000694PRO_richProline-rich region
5371PML_HUMANP29590IPR000315Znf_BboxZinc finger, B-box
5371PML_HUMANP29590IPR001841Znf_RINGZinc finger, RING-type

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